Effectiveness of the model for prenatal control of severe thalassemia.

Objective: The aim of the research was to determine effectiveness of the model for prenatal control in reducing new cases of severe thalassemia.

Methods: Pregnant women at six tertiary centers were recruited to follow the model, consisting of (1) carrier screening using mean corpuscular volume (for alpha-thal-1 and beta-thal) and CMU-E screen (for HbE trait), (2) carrier diagnosis, (3) the couples at risk were counseled and offered prenatal diagnosis, and (4) termination of affected pregnancy. All neonates were evaluated for thalassemia.

Causes and attitude of husbands toward thalassemic carrier screening test when their partners have abnormal screening tests.

Objective: To assess the attitude of husbands toward the thalassemic carrier screening test and to explore the causes of non-participation of having a blood test.

Study Design: Descriptive study.

Material And Method: During 2007-2008, 100 husbands of pregnant women with screening-positive test for thalassemia who refused to have blood test were enrolled by voluntariness.

Distribution of normal nuchal translucency thickness: a multicenter study in Thailand.

Aims: To establish the normative data distribution of nuchal translucency (NT) thickness in Thai fetuses.

Methods: A cross-sectional multicenter study was conducted among 6,455 women with singleton pregnancies and gestational age between 10 and 14 weeks. For each case, the fetal crown-rump length (CRL) and NT were measured by transabdominal ultrasound.

Chromosome analysis of uncultured amniocytes by comparative genomic hybridization in early amniocentesis.

Objective: To study chromosome analysis by comparative genomic hybridization (CGH) compared with the conventional technique in early amniocentesis.

Material And Method: Cross-sectional descriptive study design was performed in 32 singleton pregnant women with gestational age between 12-15 weeks. Transabdominal amniocentesis was carried out under ultrasound guidance.

Perinatal dengue infection.

We report a case of vertical transmission of dengue infection in an infant. The mother's was a term pregnancy with a history of chronic hypertension. She presented with high fever of 3 days duration 5 days prior to delivery.