Publications by authors named "C Voellenkle"
Article Synopsis
- Marfan syndrome (MFS) is a rare genetic disorder that affects connective tissue, leading to serious complications like thoracic aortic aneurysms (TAA), which may require preventive surgery.
- There is a need for non-invasive biomarkers and new therapeutic targets for MFS, as current monitoring methods involve complex imaging and are time-sensitive.
- Recent studies using high-throughput platforms have identified potential biomarkers and therapeutic targets related to pathways involved in MFS, but further validation in large patient groups is needed to confirm their effectiveness.
Noncoding RNAs (ncRNAs), which include circular RNAs (circRNAs) and microRNAs (miRNAs), regulate the development of cardiovascular diseases (CVD). Notably, circRNAs can interact with miRNAs, influencing their specific mRNA targets' levels and shaping a competing endogenous RNAs (ceRNA) network. However, these interactions and their respective functions remain largely unexplored in ischemic heart failure (IHF).
View Article and Find Full Text PDFRedox imbalance of the endothelial cells (ECs) plays a causative role in a variety of cardiovascular diseases. In order to better understand the molecular mechanisms of the endothelial response to oxidative stress, the involvement of circular RNAs (circRNAs) was investigated. CircRNAs are RNA species generated by a "back-splicing" event, which is the covalent linking of the 3'- and 5'-ends of exons.
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- CRISPR/Cas9 is a cutting-edge gene-editing technology showing potential for treating incurable genetic diseases like myotonic dystrophy.
- Recent experiments in models of myotonic dystrophy type 1 (DM1) have successfully targeted and removed harmful CTG-repeat expansions, leading to improvements in disease symptoms.
- The researchers developed a strategy using specific promoters to control gene editing in selected cells, ensuring effective gene therapy while minimizing unintended changes to other parts of the genome.
microRNA-210 (miR-210) is the master hypoxia-inducible miRNA (hypoxamiR) since it has been found to be significantly upregulated under hypoxia in a wide range of cell types. Gene ontology analysis of its targets indicates that miR-210 modulates several aspects of cellular response to hypoxia. Due to its high pleiotropy, miR-210 not only plays a protective role by fine-tuning mitochondrial metabolism and inhibiting red-ox imbalance and apoptosis, but it can also promote cell proliferation, differentiation, and migration, substantially contributing to angiogenesis.
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