Publications by authors named "C Vlcek"

Background: In Tanzania, inadequate infrastructures and shortages of trauma-response training exacerbate trauma-related fatalities. McGill University's Centre for Global Surgery introduced the Trauma and Disaster Team Response course (TDTR) to address these challenges. This study assesses the impact of simulation-based TDTR training on care providers' knowledge/skills and healthcare processes to enhance patient outcomes.

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Introduction: For people living with type 1 diabetes (T1D) the challenge of increasing daily physical activity (PA) is compounded by the increased risks of hypoglycemia and glucose variability. Little information exists on the lived experience of overcoming these barriers and adopting and maintaining an active lifestyle while living with T1D.

Research Design And Methods: We conducted a patient-led qualitative study consisting of semi-structured interviews or focus groups with 22 individuals at least 16 years old living with T1D.

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Article Synopsis
  • Recent discoveries of diverse microbial eukaryotes have reshaped the eukaryotic tree of life, emphasizing the significance of the Metamonada supergroup in understanding the evolution of eukaryotic cells and their mitochondrial adaptations in low-oxygen environments.* -
  • Metamonads possess mitochondrion-related organelles (MROs) that lack classical aerobic functions and have unique metabolic processes, such as ATP synthesis through substrate-level phosphorylation and hydrogen production, raising questions about their evolutionary transition from traditional mitochondria.* -
  • Through phylogenomic analysis of two newly identified anaerobic protists from the genus Anaeramoeba, researchers suggest that the common ancestor of Metamonada may have had more classical mitochondrial features,
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Euglenids represent a group of protists with diverse modes of feeding. To date, only a partial genomic sequence of Euglena gracilis and transcriptomes of several phototrophic and secondarily osmotrophic species are available, while primarily heterotrophic euglenids are seriously undersampled. In this work, we begin to fill this gap by presenting genomic and transcriptomic drafts of a primary osmotroph, Rhabdomonas costata.

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The type 2 secretion system (T2SS) is present in some Gram-negative eubacteria and used to secrete proteins across the outer membrane. Here we report that certain representative heteroloboseans, jakobids, malawimonads and hemimastigotes unexpectedly possess homologues of core T2SS components. We show that at least some of them are present in mitochondria, and their behaviour in biochemical assays is consistent with the presence of a mitochondrial T2SS-derived system (miT2SS).

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