Publications by authors named "C Villarreal"
Amphotericin B tissue penetration and pharmacokinetics in healthy and -infected rats: insights from microdialysis and population modeling.
Front Pharmacol
January 2025
Introduction: This study evaluated the relationship between total plasma and free kidney concentrations of amphotericin B (AmB) in healthy and -infected Wistar rats using microdialysis and has the potential to significantly impact future research in this field and promote the development of antifungal drugs. The findings of this study, which show that plasma levels are a good predictor for AmB kidney concentrations and can be used to optimize its dosing regimen, underscore the importance of this research.
Methods: Microdialysis probe recovery rates were determined by dialysis and retrodialysis , as well as by retrodialysis .
Article Synopsis
- The study aimed to evaluate pain management techniques used during labor by analyzing medical records and conducting interviews with new mothers.
- Findings revealed that non-pharmacological methods were more prevalent, with 61.86% in an Obstetric Center and 82.51% in a midwife-led unit, effectively reducing severe pain levels significantly.
- The use of pharmacological pain relief was much lower (15.81%) and did not lead to better pain outcomes, suggesting a need for improved strategies that align with women's preferences during labor.
Objective: Spinal cord injury (SCI) is a serious condition that can lead to partial or complete paraplegia or tetraplegia. Currently, there are few therapeutic options for these conditions, which are mainly directed toward the acute phase, such as surgical intervention and high-dose steroid administration. Mesenchymal stromal cells (MSC) have been shown to improve neurological function following spinal cord injury.
View Article and Find Full Text PDFMonnieriside A from promotes antinociceptive effects in models of inflammatory and postoperative pain in male mice.
Nat Prod Res
September 2024
Monnieriside A (MoA) is a chromone isolated from . This study investigated the antinociceptive potential of MoA in mice. MoA (0.
View Article and Find Full Text PDFArticle Synopsis
- This study compares a new sodium MRI technique called the PETALUTE sequence to a conventional technique using DA-radial spokes for imaging knee cartilage in healthy subjects.
- The results show that PETALUTE provides similar sodium quantification in cartilage while significantly reducing scan time (2:06 vs. 3:36 minutes).
- Additionally, PETALUTE can be further accelerated using compressed sensing, maintaining good structural similarity to non-accelerated images.