Publications by authors named "C Verhaak"
Article Synopsis
- Mitochondrial disease is a rare condition currently lacking approved treatments, with sonlicromanol being a promising candidate that modifies key metabolic and inflammatory pathways.
- A Phase 2b study was conducted to evaluate sonlicromanol's safety and efficacy in adults with a specific genetic mutation, involving both a randomized controlled trial (RCT) and a long-term extension study.
- While the primary endpoint of the RCT didn't show significant results, there were indications of improvement in certain cognitive and emotional assessments among patients who were more affected at baseline.
Article Synopsis
- The study aimed to explore the link between maternal depressive symptoms during pregnancy and the occurrence of infant wheezing in the first two years of life.
- Data were collected from Dutch women in the PRIDE Study, using standardized scales to assess maternal depression and a questionnaire for infant wheezing frequency postpartum.
- Results indicated that depressive symptoms in mid to late pregnancy were associated with a higher risk of infant wheezing, particularly for those with increasing symptoms throughout pregnancy, suggesting a need for further research on underlying mechanisms.
Unlabelled: A cross-sectional study was performed to evaluate health-related quality of life (HRQOL) in children with congenital vascular malformations (CVM) and to investigate factors associated with an impaired HRQOL. Children (2-17 years) with CVMs who visited the HECOVAN expertise center between 2016-2018 were included. The PedsQL 4.
View Article and Find Full Text PDFIn the Netherlands but also in many other countries, there is an increasing social discussion about gender identity and gender diversity, and an increasing number of children and adolescents are seeking medical help because of questions about their gender identity. The cause of this increase is still unknown. Gender questions are diverse and require an individual approach by a multidisciplinary team.
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