Publications by authors named "C Velasco Gimeno"
Our study assessed the characteristics of people living with HIV (PLWH) detected via opportunistic screening in Valencia (Spain) to determine diagnoses potentially missed under a more restrictive, indicator-condition diagnostic strategy. We conducted a retrospective analysis of electronic health records of 97 PLWH diagnosed between April 2019 and August 2022. The main outcomes reported were patient CD4 T cell count, known HIV risk factors at diagnosis, and missed opportunities for diagnosis, defined as the failure of a previously untested patient to undergo HIV testing despite attending previous visits to healthcare facilities prior to diagnosis.
View Article and Find Full Text PDFRole of the first WHO mutation catalogue in the diagnosis of antibiotic resistance in Mycobacterium tuberculosis in the Valencia Region, Spain: a retrospective genomic analysis.
Lancet Microbe
January 2024
Article Synopsis
- In June 2021, the WHO released a comprehensive catalogue of mutations in Mycobacterium tuberculosis that are linked to drug resistance, prompting researchers to evaluate its effectiveness for diagnosing drug-resistant tuberculosis in the relatively low prevalence area of Valencia, Spain.
- A retrospective genomic study analyzed 785 tuberculosis isolates collected between 2014-2016, utilizing whole-genome sequencing (WGS) to predict resistance profiles based on the catalogue and comparing these predictions with actual phenotypic results.
- The study found that while sensitivity for predicting resistance varied, with the highest at 85.4% for isoniazid, overall pan-susceptibility accuracy was 96.4%, highlighting some discrepancies in certain isolates that carried mutations known to cause borderline
Chronic toxicity tests on adult and larval honey bees (Apis mellifera) can require the use of dietary additives (solvents, emulsifiers, adjuvants and viscosifier agents) when the active ingredient of plant protection products cannot be dissolved or does not remain stable and homogeneous within the test diets. Acetone is the widely used and accepted solvent allowed within the international regulatory guidelines, but it can be ineffective in keeping certain compounds in solution and can cause toxicity to adults and larvae. In this publication, we present an evaluation of alternative additives in adult and larval diets.
View Article and Find Full Text PDFArticle Synopsis
- The study aims to assess the effectiveness of cefiderocol and other antibiotics against multi-drug resistant (MDR) Gram-negative bacteria, especially carbapenem-resistant strains, in Spain and Portugal.
- A total of 477 clinical isolates were evaluated, with susceptibility testing revealing that cefiderocol was highly effective, showing 99.5% susceptibility against Enterobacterales and excellent performance against other pathogens like Pseudomonas aeruginosa and Stenotrophomonas maltophilia.
- The findings support previous research indicating that cefiderocol is a promising treatment option for infections caused by MDR Gram-negative bacteria, providing an alternative to existing antibiotics.
Carbapenem-resistant is a major cause of hospital-acquired infections and the fastest-growing pathogen in Europe. Carbapenem resistance was detected at the Consorcio Hospital General Universitario de Valencia (CHGUV) in early 2015, and there has been a significant increase in carbapenem-resistant isolates since then. In this study, we collected carbapenem-resistant isolates from this hospital during the period of increase (from 2015 to 2019) and studied how carbapenem-resistant isolates emerged and spread in the hospital.
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