Publications by authors named "C Varricchio"
Article Synopsis
- T-cell acute lymphoblastic leukemia (T-ALL) is a serious blood cancer that often doesn't respond well to standard treatments and has high relapse rates, especially in adults.
- Aberrant Notch signaling is a major factor in the development and treatment resistance of T-ALL, making it an important target for personalized medicine.
- New strategies involving Notch inhibitors and BH3 mimetics are being explored for more effective treatments, highlighting their potential combined effectiveness based on recent findings.
Maintenance of NAD pools is critical for neuronal survival. The capacity to maintain NAD pools declines in neurodegenerative disease. We identify that low NMNAT2, the critical neuronal NAD producing enzyme, drives retinal susceptibility to neurodegenerative insults.
View Article and Find Full Text PDFMalignant transformation of T-cell progenitors causes T-cell acute lymphoblastic leukemia (T-ALL), an aggressive childhood lymphoproliferative disorder. Activating mutations of Notch, Notch1 and Notch3, have been detected in T-ALL patients. In this study, we aimed to deeply characterize hyperactive Notch3-related pathways involved in T-cell dynamics within the thymus and bone marrow to propose these processes as an important step in facilitating the progression of T-ALL.
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