Publications by authors named "C Vandekerkhove"
Copper-azole based formulations have been widely used to protect wood timbers against fungal decay. While these treatments are efficient for wood protection, leaching of both copper and azoles into the environment has deleterious impact on soils and surface waters. No bioremediation process is currently available for disposable of these wood wastes.
View Article and Find Full Text PDFFirst-in-human study of SBRT and adenosine pathway blockade to potentiate the benefit of immunochemotherapy in early-stage luminal B breast cancer: results of the safety run-in phase of the Neo-CheckRay trial.
J Immunother Cancer
December 2023
Article Synopsis
- Luminal B breast cancer has a poorer prognosis and lower sensitivity to chemotherapy compared to Luminal A, leading to a clinical trial (Neo-CheckRay) that explores combining stereotactic body radiation therapy (SBRT) with the drug oleclumab to enhance treatment effectiveness.
- The safety run-in of the trial involved six patients receiving a neo-adjuvant treatment regimen, including chemotherapy and immunotherapy, followed by SBRT directed at the primary tumor before surgery.
- Results showed that the treatment was generally well-tolerated with only one minor adverse event reported, and all patients successfully completed their treatments with surgery occurring 2-4 weeks afterward.
Purpose / Objective: This study compares the dosimetric plans of three distinct boost modalities in cervical cancer (CC): intracavitary (IC) with tandem/ovoids brachytherapy (BT), IC + interstitial (IS) BT, and Stereotactic-Body-Radiotherapy (SBRT). The aim is to determine the dosimetric impact in terms of target coverage and organ at risk (OAR) doses.
Materials And Methods: 24 consecutive IC + IS BT boost treatment plans were retrospectively identified.
Patient-reported outcomes in terms of swallowing and quality of life after prophylactic versus reactive percutaneous endoscopic gastrostomy tube placement in advanced oropharyngeal cancer patients treated with definitive chemo-radiotherapy: Swall PEG study.
Trials
December 2022
Background: Percutaneous endoscopic gastrostomy (PEG) is often used to provide nutritional support in locally advanced head and neck cancer patients undergoing multimodality treatment. However, there is little published data on the impact of prophylactic versus reactive PEG. PEG placement may affect swallowing-related physiology, function, and quality of life.
View Article and Find Full Text PDFBackground: Intraoperative electron radiotherapy (IOERT) can be used to treat early breast cancer during the conservative surgery thus enabling shorter overall treatment times and reduced irradiation of organs at risk. We report on our first 996 patients enrolled prospectively in a registry trial.
Methods: At Jules Bordet Institute, from February 2010 onwards, patients underwent partial IOERT of the breast.