Noise-induced properties of active dendrites.

Dendrites play an essential role in the integration of highly fluctuating input in vivo into neurons across all nervous systems. Yet, they are often studied under conditions where inputs to dendrites are sparse. The dynamic properties of active dendrites facing in vivo-like fluctuating input thus remain elusive.

Fredholm theory for the mean first-passage time of integrate-and-fire oscillators with colored noise input.

We develop a method to investigate the effect of noise timescales on the first-passage time of nonlinear oscillators. Using Fredholm theory, we derive an exact integral equation for the mean event rate of a leaky integrate-and-fire oscillator that receives constant input and temporally correlated noise. Furthermore, we show that Fredholm theory provides a unified framework to determine the system scaling behavior for small and large noise timescales.

Mechanisms underlying the response of mouse cortical networks to optogenetic manipulation.

GABAergic interneurons can be subdivided into three subclasses: parvalbumin positive (PV), somatostatin positive (SOM) and serotonin positive neurons. With principal cells (PCs) they form complex networks. We examine PCs and PV responses in mouse anterior lateral motor cortex (ALM) and barrel cortex (S1) upon PV photostimulation in vivo.

Carbon dioxide laser treatment in burn-related scarring: A prospective randomised controlled trial.

Aim: To investigate the effect of ablative fractional CO laser (AFCOL) on burns scar appearance and dermal architecture at 6 weeks and up to 3-years post-treatment.

Methods: Twenty adult patients with a burn-related scar were recruited. Inclusion criteria were a minimum scar area of 10 × 10 cm and Vancouver scar scale (VSS) score of >5 and ≥6 months since the time of injury.

Dynamics and orientation selectivity in a cortical model of rodent V1 with excess bidirectional connections.

Recent experiments have revealed fine structure in cortical microcircuitry. In particular, bidirectional connections are more prevalent than expected by chance. Whether this fine structure affects cortical dynamics and function has not yet been studied.