Ointments for the protection against organophosphate poisoning.

Ointments for the protection against poisoning of the skin by highly toxic organophosphates or organophosphate insecticides were prepared and examined for their protective effect both on guinea-pig skin in vitro and on guinea-pigs in vivo. The results of these investigations were as follows: 1. The prophylactic application of the ointments yields 20 fold reduction of the permeation rate of the toxic organophosphate compared with unprotected skin.

Radioprotection by thiazolidines at the cellular level.

Radioprotection by a number of thiazolidine derivatives was studied in vitro. Reproductive integrity of single cells was used as a parameter for survival after irradiation. Thiazolidine itself did not protect when dissolved in culture medium, but a good protective activity was found when it was dissolved in rat blood.