Publications by authors named "C Van Batten"
Background: Bluetongue virus serotype 3 (BTV-3) was detected for the first time in cattle and sheep in southern England in 2023, the first UK BTV incursion for more than 15 years. Clinical signs were not observed, yet severe clinical disease and mortality were reported during recent BTV-3 outbreaks in northern Europe.
Methods: To investigate the clinical disease and infection kinetics associated with this UK BTV-3 strain, five British sheep were infected with a UK BTV-3 isolate using Culicoides biting midges.
We created GNQA, a generative pre-trained transformer (GPT) knowledge base driven by a performant retrieval augmented generation (RAG) with a focus on aging, dementia, Alzheimer's and diabetes. We uploaded a corpus of three thousand peer reviewed publications on these topics into the RAG. To address concerns about inaccurate responses and GPT 'hallucinations', we implemented a context provenance tracking mechanism that enables researchers to validate responses against the original material and to get references to the original papers.
View Article and Find Full Text PDFArticle Synopsis
- - ELISA is a cost-effective and efficient method used to quickly detect antibodies to the epizootic hemorrhagic disease virus (EHDV) in animal blood samples.
- - The presence of EHDV antibodies indicates previous exposure but does not confirm current infection, making it necessary to combine c-ELISA with other tests like real-time PCR for accurate diagnosis.
- - The c-ELISA test targets the VP7 protein of EHDV and is endorsed by the World Organisation for Animal Health (WOAH) as a reliable tool for disease surveillance and control in ruminants.
Article Synopsis
- African swine fever virus (ASFV) has spread in Europe and Asia, and wild boar help spread this virus.
- Researchers studied how domestic pigs and wild boar get infected with ASFV by comparing their reactions and health over several days after infection.
- Wild boar got sick from the virus faster than domestic pigs and showed some differences in symptoms, but overall, both had limited virus spread in their noses and bottoms during early infections.
A recombinant, replication-defective, adenovirus-vectored vaccine expressing the H surface glycoprotein of peste des petits ruminants virus (PPRV) has previously been shown to protect goats from challenge with wild-type PPRV at up to 4 months post vaccination. Here, we present the results of a longer-term trial of the protection provided by such a vaccine, challenging animals at 6, 9, 12 and 15 months post vaccination. Vaccinated animals developed high levels of anti-PPRV H protein antibodies, which were virus-neutralising, and the level of these antibodies was maintained for the duration of the trial.
View Article and Find Full Text PDF