Histidine orientation in artificial peroxidase regioisomers as determined by paramagnetic NMR shifts.

Fe-Mimochrome VI*a is a synthetic peroxidase and peroxygenase, featuring two different peptides that are covalently-linked to deuteroheme. To perform a systematic structure/function correlation, we purposely shortened the distance between the distal peptide and the heme, allowing for the separation and characterization of two regioisomers. They differ in both His axial-ligand orientation, as determined by paramagnetic NMR shifts, and activity.

Identification of RAG-like transposons in protostomes suggests their ancient bilaterian origin.

Background: V(D) J recombination is essential for adaptive immunity in jawed vertebrates and is initiated by the RAG1-RAG2 endonuclease. The and genes are thought to have evolved from a (RAG-like) transposon containing convergently-oriented () and genes. Elements resembling this presumptive evolutionary precursor have thus far only been detected convincingly in deuterostomes, leading to the model that the transposon first appeared in an early deuterostome.

Fatigue Behavior of Crystalline-Reinforced Glass-Ceramics.

Purpose: To evaluate the fatigue behavior of two crystalline-reinforced ceramics: leucite-reinforced (VL) and lithium disilicate-based (VD) glass-ceramics.

Materials And Methods: Bar-shaped specimens (16 × 4 × 1.2 mm) were produced for each ceramic using prefabricated CAD/CAM blocks.

Rendu-Osler-Weber syndrome: dermatological approach.

The Rendu-Osler-Weber syndrome is a rare systemic fibrovascular dysplasia, recognized by mucocutaneous telangiectasias, arteriovenous malformations, epistaxis and family history. Recurrent bleeding, hypoxemia, congestive heart failure, portosystemic encephalopathy, and symptoms related to angiodysplasia of the central nervous system may occur. Since the treatment is based on supportive measures, early recognition is of utmost importance.

Brazilian spotted fever: the importance of dermatological signs for early diagnosis.

Brazilian spotted fever is an acute febrile infectious disease caused by Rickettsia rickettsii, transmitted by tick bite. As this disease is rare and has high mortality rates in Brazil, the clinical aspects and epidemiological data may help the diagnosis. We report a case of Brazilian spotted fever in a 19-year-old patient who presented maculopapular exanthema in the palmar region and upper limbs, lymphadenopathy, fever, chills, headache, conjunctival hyperemia, nausea, vomiting, dyspnea, myalgia, developing neurological signs and abdominal pain.