Publications by authors named "C V Madjar"

The HEALthy Brain and Child Development (HBCD) Study, a multi-site prospective longitudinal cohort study, will examine human brain, cognitive, behavioral, social, and emotional development beginning prenatally and planned through early childhood. The acquisition of multimodal magnetic resonance-based brain development data is central to the study's core protocol. However, application of Magnetic Resonance Imaging (MRI) methods in this population is complicated by technical challenges and difficulties of imaging in early life.

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We present the Canadian Open Neuroscience Platform (CONP) portal to answer the research community's need for flexible data sharing resources and provide advanced tools for search and processing infrastructure capacity. This portal differs from previous data sharing projects as it integrates datasets originating from a number of already existing platforms or databases through DataLad, a file level data integrity and access layer. The portal is also an entry point for searching and accessing a large number of standardized and containerized software and links to a computing infrastructure.

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Background: Rare diseases are estimated to affect 150-350 million people worldwide. With advances in next generation sequencing, the number of known disease-causing genes has increased significantly, opening the door for therapy development. Rare disease research has therefore pivoted from gene discovery to the exploration of potential therapies.

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Article Synopsis
  • To advance Alzheimer Disease (AD) research, it's important to gather and share large datasets, which is addressed in the PREVENT-AD cohort study focusing on cognitively healthy older individuals with family histories of AD.
  • Between 2011 and 2017, 386 participants were enrolled, with 349 consenting to share their data, which includes various types of health and imaging information collected over five years.
  • The gathered data is openly accessible through the Canadian Open Neuroscience Platform, allowing qualified researchers to explore sensitive information while contributing to ongoing understanding of AD causes.
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The Cuban Human Brain Mapping Project (CHBMP) repository is an open multimodal neuroimaging and cognitive dataset from 282 young and middle age healthy participants (31.9 ± 9.3 years, age range 18-68 years).

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