Computationally efficient collimator-detector response compensation in high energy SPECT using 1D convolutions and rotations.

. Modeling of the collimator-detector response (CDR) in single photon emission computed tomography (SPECT) reconstruction enables improved resolution and accuracy, and is thus important for quantitative imaging applications such as dosimetry. The implementation of CDR modeling, however, can become a computational bottleneck when there are substantial components of septal penetration and scatter in the acquired data, since a direct convolution-based approach requires large 2D kernels.

Physical and Surface Chemical Analysis of High-Quality Antimicrobial Cotton Fabrics Functionalized with CuO Grown from Different Copper Salts: Experimental and Theoretical Approach.

The emergence of harmful microorganisms poses a public health challenge. Antimicrobial cotton textiles with semiconductor oxides offer a promising solution to mitigate pathogen spread. Here, we study the physicochemical interactions between copper oxides (CuO) and cellulose in cotton fiber functionalized with these same oxides for antimicrobial properties.

Impact of diabetes on epicardial reperfusion and mortality in a contemporary STEMI population undergoing mechanical reperfusion: Insights from the ISACS STEMI COVID 19 registry.

Background And Aim: Diabetes has been shown in last decades to be associated with a significantly higher mortality among patients with ST-segment elevation myocardial infarction (STEMI) treated with primary PCI (PPCI). Therefore, the aim of current study was to evaluate the impact of diabetes on times delays, reperfusion and mortality in a contemporary STEMI population undergoing PPCI, including treatment during the COVID pandemic.

Methods And Results: The ISACS-STEMI COVID-19 is a large-scale retrospective multicenter registry involving PPCI centers from Europe, Latin America, South-East Asia and North-Africa, including patients treated from 1st of March until June 30, 2019 and 2020.

Impact of cell geometry, cellular uptake region, and tumour morphology on Ac and Lu dose distributions in prostate cancer.

Background: Radiopharmaceutical therapy with Ac- and Lu-PSMA has shown promising results for the treatment of prostate cancer. However, the distinct physical properties of alpha and beta radiation elicit varying cellular responses, which could be influenced by factors such as tumour morphology. In this study, we use simulations to examine how cell geometry, region of pharmaceutical uptake within the cell to model different internalization fractions, and the presence of tumour hypoxia and necrosis impact nucleus absorbed doses and dose heterogeneity with Ac and Lu.

Synthesis and Evaluation of Ga- and Lu-Labeled [Pro]bombesin(8-14) Derivatives for Detection and Radioligand Therapy of Gastrin-Releasing Peptide Receptor-Expressing Cancer.

The gastrin-releasing peptide receptor (GRPR) is overexpressed in a variety of cancers and represents a promising target for diagnosis and therapy. However, the extremely high accumulation in the pancreas observed for most of the clinically evaluated GRPR-targeted radiopharmaceuticals could limit their applications. In this study, we synthesized one GRPR antagonist (ProBOMB5) and two GRPR agonists (LW02056 and LW02057) by replacing the 4-thiazolidinecarboxylic acid (Thz) residue in our previously reported GRPR-targeted tracers with Pro.