Publications by authors named "C U Monjaras-Avila"
Article Synopsis
- Bladder cancer primarily impacts men with higher rates of incidence and mortality, highlighting the need for better predictive models in treatment.
- This study presents a novel 3D in vitro tumor model using decellularized pig bladders, which effectively replicates the tumor microenvironment and overcomes limitations of traditional 2D cultures.
- The model demonstrated efficacy in drug screening with significant predictive reliability (83.3%) for treatment responses, outperforming conventional 2D systems.
Article Synopsis
- This study addresses the ongoing kidney shortage for transplantation in patients with end-stage renal disease (ESRD) by exploring tissue engineering as a potential solution.
- Researchers used pig kidneys, which are similar to human kidneys, and removed their cells through a process called decellularization to retain their structure.
- By infusing pig kidney cells and human red blood cells into these decellularized kidneys, the study shows promising results that could lead to increasing the availability of transplantable organs for ESRD patients.
Clear cell renal cell carcinoma (ccRCC) is a type of kidney cancer that arises from the cells lining the tubes of the kidney. The tumor immune microenvironment (TIME) of ccRCC is a complex interplay of various immune cells, cytokines, and signaling pathways. One of the critical features of the ccRCC TIME is the presence of infiltrating immune cells, including T cells, B cells, natural killer cells, dendritic cells, and myeloid-derived suppressor cells.
View Article and Find Full Text PDFBackground: Renal cell carcinoma (RCC) is a highly vascular tumor and patients with low risk metastatic RCC of clear-cell histological sub-type (mccRCC) are treated with tyrosine-kinase inhibitors (TKIs), sunitinib, as the first-line of treatment. Unfortunately, TKI resistance eventually develops, and the underlying molecular mechanism is not well understood.
Methods: RCC cell-line with metastatic clear-cell histology (Caki-1), and patient samples were analysed to identify the role of Y-box binding protein 1 (YB-1) and ATP-binding cassette sub-family B member 1 (ABCB-1) in acquired sunitinib-resistance development.
Clear-cell renal cell carcinoma (ccRCC) is a common therapy resistant disease with aberrant angiogenic and immunosuppressive features. Patients with metastatic disease are treated with targeted therapies based on clinical features: low-risk patients are usually treated with anti-angiogenic drugs and intermediate/high-risk patients with immune therapy. However, there are no biomarkers available to guide treatment choice for these patients.
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