Publications by authors named "C U Lorentz"
Lipopolysaccharide (LPS) is the primary pathogenic factor in Gram-negative sepsis. While the presence of LPS in the bloodstream during infection is associated with disseminated intravascular coagulation, the mechanistic link between LPS and blood coagulation activation remains ill-defined. The contact pathway of coagulation-a series of biochemical reactions that initiates blood clotting when plasma factors XII (FXII) and XI (FXI), prekallikrein (PK) and high molecular weight kininogen (HK) interact with anionic surfaces-has been shown to be activated in Gram-negative septic patients.
View Article and Find Full Text PDFObjective: To assess the opinion, practices, and challenges of international key opinion leaders about two minimal invasive surgical techniques in supraglottic laryngeal tumours: transoral laser microsurgery (TLM) and the transoral robotic surgery (TORS).
Methods: Design of a questionnaire composed of seven sections and fifty questions covering descriptive data of participants, practitioners experience procedural sequences, considerations related to airways, feeding, and voice, intraoperative haemorrhage, postoperative management, and a comparative analysis of TLM and TORS in treating supraglottic laryngeal cancer.
Results: A total of 27 head and neck surgeons replied to the survey.
Article Synopsis
- Tick-borne encephalitis (TBE) is caused by the TBE virus and typically presents milder symptoms in children, yet there's limited data on its incidence in this age group.* -
- A study at the University Hospital of Strasbourg identified four confirmed cases of TBE among pediatric patients from 2020 to 2022, resulting in an incidence rate of 1.51 cases per 100,000 inhabitants.* -
- The findings emphasize the importance of early diagnosis and follow-up care for affected children, as well as reconsidering vaccination guidelines due to observed cases among unvaccinated patients.*
Two-dimensional gas chromatography (GC × GC) and two-dimensional liquid chromatography (LC × LC) are nowadays widely used in academia and industry due to their high separation power. However, as far as we know, the complementarity of these two techniques has not yet been thoroughly studied based on the analysis of the same sample. Therefore, this was undertaken here by analysing the liquid fraction obtained after depolymerising a natural waste - lignin - with GC × GC and off-line comprehensive LC × SFC (SFC: supercritical fluid chromatography).
View Article and Find Full Text PDFArticle Synopsis
- Loss of endothelial barrier function is linked to inflammatory diseases, and coagulation factor XI (FXI) plays a significant role in this process.
- The study found that FXIa increases endothelial cell permeability by cleaving VE-cadherin, which is involved in cell adhesion.
- This cleavage is mediated by the activation of ADAM10 and leads to a signaling cascade via VEGFR2 that enhances ADAM10 expression, suggesting FXIa could contribute to inflammatory disease development by disrupting the endothelial barrier.