Publications by authors named "C Tuleu"
Article Synopsis
- The study focuses on improving the taste of pediatric medicines by understanding children's taste preferences and sensitivities, which is crucial for compliance with oral medications.
- Researchers utilized computer-vision techniques to analyze children's facial reactions to different flavored taste strips (no taste, bitter, sweet, sour) by recording videos and scoring responses using the Aparito Atom app.
- Results indicated that children preferred sweetness and disliked bitterness, while their facial expressions—like eyebrow and mouth movements—served as significant indicators of their taste preferences, suggesting a method for developing better palatable drug formulations.
Personalised medicine, facilitated by advancements like 3D printing, may offer promise in oncology. This scoping review aims to explore the applicability of 3D printing for personalised pharmaceutical dosage forms in paediatric cancer care, focusing on treatment outcomes and patient experiences. Following the Joanna Briggs Institute (JBI) methodology, a comprehensive search strategy was implemented to identify the relevant literature across databases including PubMed, Embase, and Web of Science.
View Article and Find Full Text PDFThis publication is the first to report current, global, pediatric oral extemporaneous compounding practices. Complete survey responses were received from 479 participants actively involved in compounding across all the World Health Organization (WHO) regions. The survey addressed oral formulation of extemporaneous liquids, including the use of commercial or in-house vehicles, flavoring excipients, source of formulation recipes, and beyond use dates (BUDs).
View Article and Find Full Text PDFMedicines for children often taste bitter, presenting a significant challenge to treatment compliance. However, most studies on paediatric drug development rely on adult volunteers for sensory research, and the level of expertise required from these assessors is unclear. This study aimed to address this gap by investigating perceived bitterness aversion to taste strips impregnated with different concentrations of quinine hydrochloride in 439 school-aged children.
View Article and Find Full Text PDFIt is well established that treatment regime compliance is linked to the acceptability of a pharmaceutical formulation, and hence also to therapeutic outcomes. To that end, acceptability must be assessed during the development of all pharmaceutical products and especially for those intended for paediatric patients. Although acceptability is a multifaceted concept, poor sensory characteristics often contribute to poor patient acceptability.
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