Publications by authors named "C Tuccilli"
Article Synopsis
- Increased expression of the uPA system is linked to tumor growth and poor prognosis in several cancers, including thyroid carcinomas, making it a potential target for treatment.
- WX-340, a specific uPA inhibitor, was tested on aggressive thyroid cancer cells and showed reduced cell adhesion and invasion but increased uPA receptor levels.
- Despite its effects on cell behavior, WX-340 did not significantly lower tumor growth in animal models, suggesting that targeting uPA might not be enough for effective therapy.
The transcription factors involved in epithelial-mesenchymal transition (EMT-TFs) silence the genes expressed in epithelial cells (e.g., E-cadherin) while inducing those typical of mesenchymal cells (e.
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- A new immunotherapy that targets the PD-1 receptor and PD-L1 ligand shows promise for treating hard-to-treat cancers, like poorly differentiated and anaplastic thyroid cancers.
- The review summarizes how PD-L1 is expressed in various thyroid cancer types and its correlation with clinical features and prognosis.
- It highlights the PD-1/PD-L1 interaction as a potential effective treatment strategy for thyroid cancer.
Article Synopsis
- The study investigates how the dysregulation of immune checkpoint ligands PD-L1, PD-L2, CTLA-4, CD80, and CD86 allows thyroid tumors to evade immune detection, focusing on papillary thyroid carcinoma (PTC) and anaplastic thyroid carcinoma (ATC).
- In 94 patients with PTC and 11 with ATC, the expression levels of these ligands at the mRNA level were evaluated, revealing widespread deregulation in cancer tissues compared to healthy tissues.
- Specific gene expression patterns were linked to clinicopathological features, such as longer disease-free survival associated with increased expression in PTC and the correlation of higher expression with BRAF mutations and lymph node metastasis.
The skin is the largest organ of the body, at the boundary with the outside environment. Primarily, it provides a physical and chemical barrier against external insults, but it can act also as immune organ because it contains a whole host of immune-competent cells of both the innate and the adaptive immune systems, which cooperate in eliminating invading pathogens following tissue injury. On the other hand, improper skin immune responses lead to autoimmune skin diseases (AISD), such as pemphigus, bullous pemphigoid, vitiligo, and alopecia.
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