Publications by authors named "C Tselepis"
The process of microencapsulation and the development of microparticle-based drug formulations have gained increased pharmaceutical interest, particularly for drug delivery and bacterial-encapsulation purposes for probiotic delivery. Existing studies have examined microcomposite (MC) responses to gastrointestinal (GI) conditions with the aim of controlling disintegration, and thus release, across the small and large bowel. However, the delivery of MCs which remain intact, without degrading, could act as bacterial growth scaffolds or materials providing a prebiotic support, conferring potentially beneficial GI health properties.
View Article and Find Full Text PDFThe detrimental effects of high concentrations of colonic iron have been linked to intestinal inflammation and microbial dysbiosis. Exploiting chelation against this pool of iron may restore intestinal health and have beneficial impacts on microbial communities. This study aimed to explore whether lignin, a heterogenous polyphenolic dietary component, has iron-binding affinity and can sequester iron within the intestine and thus, potentially modulate the microbiome.
View Article and Find Full Text PDFArticle Synopsis
- - A systematic review investigated predictive biomarkers for successful faecal microbiota transplantation (FMT) in treating ulcerative colitis, finding that donor and recipient microbial and metabolic factors might play a key role in response rates.
- - The analysis included 25 studies showing that responding patients had increased microbial diversity and higher levels of certain bacteria (Clostridiales and Bacteroides), with short chain fatty acid production linked to FMT success.
- - Key predictors for positive outcomes included younger age, less severe disease, higher species richness in stool samples, and microbial similarity between donor and recipient, suggesting the potential for personalized treatment approaches in future clinical research.
The toxic effects of excess dietary iron within the colonic lumen are well documented, particularly in the context of Inflammatory Bowel Disease (IBD) and Colorectal Cancer (CRC). Proposed mechanisms that underpin iron-associated intestinal disease include: (1) the pro-inflammatory and ROS-promoting nature of iron, (2) gene-expression alterations, and (3) intestinal microbial dysbiosis. However, to date no studies have examined the effect of iron on the colonic epigenome.
View Article and Find Full Text PDFTetraspanin 6 is a regulator of carcinogenesis in colorectal cancer.
Proc Natl Acad Sci U S A
September 2021
Article Synopsis
- * The absence of Tspan6 activates certain signaling pathways associated with increased production of tmTGF-α, a factor linked to tumor growth and progression, influenced by the adaptor protein syntenin-1.
- * Low levels of Tspan6 in CRC are associated with poorer survival rates, while higher expression is linked to better responses to EGFR-targeted therapies, such as Cetuximab, particularly in patients with right-sided tumors and KRAS mutations.