Reversible Electrocatalytic NAD/NADH Interconversion Mediated by a Pyrazine-Amidate Iridium Complex.

Herein, we report reversible electrocatalytic NAD/NADH interconversion mediated by [Cp*Ir(pyza)Cl] (, pyza = pyrazine amidate). was designed through a rational approach aimed at lowering the overpotential of NAD to NADH reduction with respect to that observed for electrocatalyst [Cp*Ir(pica)Cl] (, pica = picolinamidate). The peculiar properties of pyza, which is substantially less σ electron-donator and more π electron-acceptor than pica, resulted in an easier bielectronic reduction process occurring at -0.

Boosting Effect of Sterically Protected Glucosyl Substituents in Formic Acid Dehydrogenation by Iridium(III) 2-Pyridineamidate Catalysts.

[Cp*Ir(R-pica)Cl] (Cp*=pentamethylcyclopentadienyl anion, pica=2-picolineamidate) complexes bearing carbohydrate substituents on the amide nitrogen atom (R=methyl-β-D-gluco-pyranosid-2-yl, 1; methyl-3,4,6-tri-O-acetyl-β-D-glucopyranosid-2-yl, 2) were tested as catalysts for formic acid dehydrogenation in water. TOF values over 12000 h and 50000 h were achieved at 333 K for 1 and 2, respectively, with TON values over 35000 for both catalysts. Comparison with the simpler cyclohexyl-substituted analogue (3) indicated that glucosyl-based complexes are much better performing under the same experimental conditions (TOF=5144 h, TON=5000 at pH 2.

Normospermic Patients Infected With Role of Dysregulated miR-122-5p, miR-34c-5, and miR-141-3p.

Background: (UP) is a causative agent of non-gonococcal urethritis, involved in the pathogenesis of prostatitis and epididymitis, and it could impair human fertility. Although UP infection is a frequent cause of male infertility the study evidence assessing their prevalence and the association in patients with infertility is still scarce. The molecular processes leading to defects in spermatozoa quality are not completely investigated.

Targeting strategies for modulating pre-mRNA splicing with small molecules: Recent advances.

The concept of using small molecules to therapeutically modulate pre-mRNA splicing was validated with the US Food and Drug Administration (FDA) approval of Evrysdi® (risdiplam) in 2020. Since then, efforts have continued unabated toward the discovery of new splicing-modulating drugs. However, the drug development world has evolved in the 10 years since risdiplam precursors were first identified in high-throughput screening (HTS).

Biosynthesis of silver nanoparticles using actinomycetes, phytotoxicity on rice seeds, and potential application in the biocontrol of phytopathogens.

To find effective silver nanoparticles (AgNPs) for control of phytopathogens, in this study, two strains of actinomycetes isolated from the soil of the Brazilian biome Caatinga (Caat5-35) and from mangrove sediment (Canv1-58) were utilized. The strains were identified by using the 16S rRNA gene sequencing as Streptomyces sp., related to Streptomyces mimosus species.