Publications by authors named "C Trenkwalder"
Background: Leucencephalopathy (LE) is often detected on magnetic resonance imaging in elderly patients. These white matter lesions may interfere with lead trajectories for deep brain stimulation (DBS) in patients with Parkinson's disease (PD) and are associated with complications after DBS surgery.
Objective: This study was conducted to assess the incidence of LE in PD patients and to evaluate correlations with complications after DBS surgery.
Background: Preferences for risk disclosure in population-based studies assessing Parkinson's disease (PD) risk have not been assessed so far.
Objectives: To examine preferences for risk disclosure in a subset of the European Healthy Brain Aging (HeBA) multicenter study.
Methods: After a remote PD risk assessment, a structured pilot-questionnaire on risk disclosure was first presented to participants (≥50 years, without neurodegenerative diseases) during in-person visits at the Innsbruck study site.
Article Synopsis
- Fluorescence microscopy has advanced to subnanometer resolution but struggles to visualize single proteins or small complexes; researchers have developed a method called ONE microscopy to address this.
- ONE microscopy expands specimens, tags them with fluorophores, and captures videos to analyze fluorescence fluctuations, allowing for the visualization of individual proteins' shapes at around 1-nm resolution.
- This technique can observe protein conformational changes and has potential applications in clinical settings, such as analyzing protein aggregates in cerebrospinal fluid from Parkinson's patients, bridging high-resolution biology and light microscopy for new discoveries.
Article Synopsis
- Accurate diagnosis of Parkinson's disease (PD) requires modern criteria that consider clinical, imaging, biomarker, and genetic information.
- The revised guidelines from the German Society for Neurology adopt a broader understanding of PD, recognizing both idiopathic and hereditary forms, and emphasize the 2015 Movement Disorders Society criteria.
- Enhanced diagnostic practices through long-term monitoring, the inclusion of non-motor symptoms, and the use of imaging and genetic testing support better patient-centered care for those with PD.