α-Lipoic Acid Ameliorates Arsenic-Induced Lipid Disorders by Promoting Peroxisomal β-Oxidation and Reducing Lipophagy in Chicken Hepatocyte.

Liver disease poses a significant threat to global public health, with arsenic (As) recognized as a major environmental toxin contributing to liver injury. However, the specific mechanisms and the protective effects of α-lipoic acid (LA) remain unclear. Therefore, this study employs network toxicology and network pharmacology to comprehensively analyze the hepatotoxic mechanism of As and the hepatoprotective mechanism of LA, and further verifies the mechanisms of peroxisomal β-oxidation and lipophagy in the process.

Comparison of water exchange measurements between filter-exchange imaging and diffusion time-dependent kurtosis imaging in the human brain.

Purpose: Filter-exchange imaging (FEXI) and diffusion time (t)-dependent kurtosis imaging (DKI(t)) are two diffusion-based methods that have been proposed for in vivo measurements of water exchange rates. Few studies have directly compared these methods. We aimed to investigate whether FEXI and DKI(t) yield comparable water exchange measurements in the human brain in vivo.

A Novel Gene DUSP8 Missense Mutation Causes Nonsyndromic Hereditary Gingival Fibromatosis by Dysregulating Lysine Lactylation.

Aims: The goal of this study was to explore new candidate genes and pathogenesis mechanisms of nonsyndromic hereditary gingival fibromatosis (nsHGF) and to provide an experimental basis for the diagnosis of nsHGF.

Methods: Whole-exome sequencing (WES) was performed on peripheral blood DNA from three nsHGF family members to screen for new candidate genes, and Sanger sequencing and related databases were used to verify the pathogenicity of this gene deficiency. Moreover, the effects of gene deficiency on the biological characteristics of human gingival fibroblasts (HGFs) were evaluated via cell proliferation assays, extracellular matrix (ECM) deposition detection, cell apoptosis and cell cycle assessment, cell migration and gene expression analyses.

Porous spontaneously polarized ceramic-reinforced ozone micro-nano bubbles for efficient oxidation of starch: Reaction uniformity, physicochemical properties, and mechanism.

The preparation of food-grade oxidized starch with eco-friendly ozone (O) as oxidant is limited by low mass transfer and reaction efficiency. This study proposed a porous spontaneously polarized ceramic-reinforced O micro-nano bubbles (PSPC-OMNB) technology to prepare oxidized cassava starch (PSPC-OMCS). Meanwhile, reaction uniformity, physicochemical properties, and formation mechanisms were emphasized for comprehensive investigation.