Publications by authors named "C Tomruk"
Histopathology of thermal effects in endoscopic ear surgery: An experimental animal study.
Laryngoscope Investig Otolaryngol
December 2024
Objective: The potential risk of thermal damage in the transcanal endoscopic ear surgery has been a concerning issue. This study aimed to investigate the histopathological effects of heat exposure of different durations in external auditory canal (EAC) skin and facial nerve tissues.
Methods: This study was conducted on 20 rabbits assigned equally to five groups according to the endoscope-transmitted heat exposure duration: Control group (no exposure), 2, 10, 15, and 30 min.
Introduction: Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impaired social interactions and repetitive behaviors. This study examines the effects of fenofibrate on a propionic acid (PPA)-induced rat model of ASD, focusing on behavioral changes, inflammatory markers, and histological findings.
Materials And Methods: Thirty male Wistar rats were divided into three groups: a control group, a group receiving PPA and saline, and a group treated with PPA and fenofibrate for 15 days.
Article Synopsis
- The study investigates the effects of pentoxifylline on autism-like behaviors in rat models induced by propionic acid (PPA), focusing on how it influences brain proteins and inflammatory responses.
- Thirty male Wistar albino rats were divided into three groups: a control group, a PPA group, and a PPA plus pentoxifylline group, with various treatment regimens followed by analysis of brain and blood samples.
- Results showed that pentoxifylline significantly reduced autism-like behaviors, lowered levels of the pro-inflammatory cytokine TNF-α, increased beneficial brain factors like ATP and nerve growth factor, and improved neuronal health, suggesting its potential as a neurotherapeutic agent for autism.
The aim of this study was to investigate the possible protective effects of apelin, which is known to have antioxidant and anti-inflammatory effects, on changes in neurogenesis in newborns of pregnant rats with L-NAME-induced preeclampsia. Wistar albino female rats were divided into four experimental groups: Control, Apelin, Preeclampsia and Preeclampsia + Apelin. Blood pressure was measured on the 5th, 11th and 17th days of gestation, urine protein was analyzed from urine samples collected for 24 h on the 6th, 12th and 18th days and serum creatinine was analyzed from serum samples.
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- Chronic subdural hematoma (cSDH) is increasingly common in aging populations, and while surgery is standard, treatments like dexamethasone (Dex) and atorvastatin (Ato) are being researched for high-risk patients despite a higher mortality risk.
- A study was conducted with 95 rats to analyze the effects of dexamethasone-atorvastatin versus bevacizumab (Bev), using autologous blood injections to simulate cSDH, and monitoring health through weight changes.
- Results showed both treatment groups were effective, with maximum immune response on day 14, but Dex-Ato caused weight loss, while Bev was better tolerated and emerged as a potential alternative treatment for c