Publications by authors named "C Tomlinson"
This study explores digital inclusion for youth in out-of-home placement within the child welfare system, a group impacted by significant social determinants affecting health. Recognized as a "super social determinant of health," digital inclusion holds promise in addressing key health factors, such as social relationships, support systems, and information access. The study surveyed 131 foster parents and 152 kinship providers across varied U.
View Article and Find Full Text PDFObjectives: To investigate healthcare utilisation and cost in individuals with long COVID (LC) at population level.
Design: Case-control cohort analysis with multiple age-, sex-, ethnicity-, deprivation-, region- and comorbidity-matched control groups: (1) COVID only, no LC; (2) pre-pandemic; (3) contemporary non-COVID; and (4) pre-LC (self-controlled, pre-COVID pandemic).
Setting: National, population-based, linked UK electronic health records (British Heart Foundation/NHS England Secure Data Environment).
Background: This study estimated to what extent the number of measurements of cardiometabolic risk factors (e.g., blood pressure, cholesterol, glycated haemoglobin) were impacted by the COVID-19 pandemic and whether these have recovered to expected levels.
View Article and Find Full Text PDFRecent successes in developing small molecule degraders that act through the ubiquitin system have spurred efforts to extend this technology to other mechanisms, including the autophagosomal-lysosomal pathway. Therefore, reports of autophagosome tethering compounds (ATTECs) have received considerable attention from the drug development community. ATTECs are based on the recruitment of targets to LC3/GABARAP, a family of ubiquitin-like proteins that presumably bind to the autophagosome membrane and tether cargo-loaded autophagy receptors into the autophagosome.
View Article and Find Full Text PDFArticle Synopsis
- Recent research on mRNA therapeutics has increased due to COVID-19, with applications in vaccination, cancer therapy, and immune modulation, but they face challenges like instability and degradation.
- Traditional agarose gel electrophoresis has been the standard for analyzing RNA, but newer methods, like those using the Agilent 2100 Bioanalyzer, offer better quality assessment despite being more expensive and less accessible.
- The proposed full-lane quantification (FLQ) method integrates ImageJ with programming in Python and R to provide a quick and affordable way to evaluate mRNA degradation, yielding results comparable to those from more sophisticated systems.