Double CHEK2 Pathogenic and Low-Risk Variants and Associated Cancer Phenotypes.

Importance: CHEK2 pathogenic and likely pathogenic variants (PVs) are common, and low-risk (LR) variants, p.I157T, p.S428F, and p.

Cancer burden in individuals with single versus double pathogenic variants in cancer susceptibility genes.

Purpose: As panel testing expands, more individuals with double pathogenic variants (DPVs) in cancer susceptibility genes are likely to be identified. Little is known about the effects of DPVs on cancer phenotype, although this information is crucial for genetic counseling and risk management. We sought to describe the cancer phenotype among individuals with DPVs in cancer susceptibility genes.

Variant of uncertain significance (VUS) patterns among patients with early-onset colorectal cancer.

The increasing burden of colorectal cancer among adults age<50 (early-onset CRC) and new National Comprehensive Cancer Network guidelines recommending universal genetic testing in early-onset CRC emphasize the need for accurate/timely variant classification in clinical care. Here, we investigated germline variant of uncertain significance (VUS) patterns among diverse individuals with early-onset CRC. A total of 3,980 individuals age 15-49 when diagnosed with a first primary CRC-including 1,001 cases identifying as non-White, who underwent genetic testing for 14 CRC susceptibility genes performed by a clinical testing laboratory were included.

A qualitative analysis of perceived risks and benefits of mosquito abatement and bite prevention strategies in Northeastern U.S. communities.

Mosquito-borne disease (MBD) incidence is increasing in the United States (U.S.), presenting an evolving health threat.

The British Sleep Society position statement on Daylight Saving Time in the UK.

There is an ongoing debate in the United Kingdom and in other countries about whether twice-yearly changes into and out of Daylight Saving Time should be abolished. Opinions are divided about whether any abolition of Daylight Saving Time should result in permanent Standard Time, or year-long Daylight Saving Time. The British Sleep Society concludes from the available scientific evidence that circadian and sleep health are affected negatively by enforced changes of clock time (especially in a forward direction) and positively by the availability of natural daylight during the morning.