Effects of Rurality, Socioeconomic Status, and Race on Head and Neck Squamous Cell Carcinoma Outcomes.

Objective: To examine how rural residence interacts with SES and race/ethnicity relative to Head and neck squamous cell carcinoma (HNSCC) treatment delay and outcomes.

Methods: The SEER database was queried for patients aged ≥18 with HNSCC. Out of 164,337 cases, 126,052 remained after exclusions for missing data.

PRMT5-regulated splicing of DNA repair genes drives chemoresistance in breast cancer stem cells.

Breast cancer stem cells (BCSCs) are a rare cell population that is responsible for tumour initiation, metastasis and chemoresistance. Despite this, the mechanism by which BCSCs withstand genotoxic stress is largely unknown. Here, we uncover a pivotal role for the arginine methyltransferase PRMT5 in mediating BCSC chemoresistance by modulating DNA repair efficiency.

Bee Habitat, but Not Bee Community Structure, Varies Across Grassland Management in Four National Parks in the Mid-Atlantic, USA.

National Park Service units in the United States play a large role in providing habitat for native pollinators. In parks that are established to preserve cultural landscapes, park managers recognize an opportunity to improve pollinator habitat while maintaining historically accurate conditions. In this study, we document floral resources and native bees within managed park grasslands, with the goal of providing information to managers to help them maximize pollinator habitat while meeting other management objectives.