Publications by authors named "C Tlemsani"
Article Synopsis
- Sarcomas are not typically associated with Lynch Syndrome (LS), but recent literature suggests a connection, prompting a national study to investigate their characteristics in LS patients.
- The SarcLynch study included 81 patients, finding that 83% had soft-tissue sarcomas, particularly pleomorphic variants like undifferentiated pleomorphic sarcoma and pleomorphic rhabdomyosarcoma, with 40% having sarcoma as their first cancer event.
- Results showed a high prevalence of mismatch repair deficiency and promising responses to immune checkpoint inhibitors, suggesting the need for screening and potential immunotherapy for these sarcomas.
Introduction: The low incidence and heterogeneity of sarcomas limit understanding of their progression in metastatic cases. The use of metastasectomy is debated due to lack of consensus and evidence-based data. This study aimed to identify simple prognostic factors that could contribute to the therapeutic strategy.
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- The study aimed to assess how well artificial intelligence (AI) can detect lung metastases in preoperative CT scans compared to radiologists.
- AI was applied to CT scans of 167 patients, showing that it detected a high percentage of true nodules and significantly improved the overall sensitivity when used alongside human radiologists.
- The findings suggest that AI not only enhances detection rates but can also identify cancers earlier, which could be beneficial for patient care.
Sarcomas are a diverse group of rare malignancies composed of multiple different clinical and molecular subtypes. Due to their rarity and heterogeneity, basic, translational, and clinical research in sarcoma has trailed behind that of other cancers. Outcomes for patients remain generally poor due to an incomplete understanding of disease biology and a lack of novel therapies.
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- The study examines the effectiveness and safety of immune checkpoint inhibitors in patients with Li-Fraumeni syndrome, a condition that increases cancer risk.
- Researchers conducted a series of cases to assess patient responses to this type of cancer treatment, gathering data on outcomes and side effects.
- Findings suggest that immune checkpoint blockade may offer potential benefits in treating cancers in individuals with Li-Fraumeni syndrome, but further research is needed to confirm these results.