Publications by authors named "C Tikellis"
Methylglyoxal (MGO) is a reactive glucose metabolite linked to diabetic cardiovascular disease (CVD). MGO levels surge during intermittent hyperglycemia. We hypothesize that these MGO spikes contribute to atherosclerosis, and that pyridoxamine as a MGO quencher prevents this injury.
View Article and Find Full Text PDFCirculating levels of soluble ACE2 are increased by diabetes. Although this increase is associated with the presence and severity of cardiovascular disease, the specific role of soluble ACE2 in atherogenesis is unclear. Previous studies suggested that, like circulating ACE, soluble ACE2 plays a limited role in vascular homeostasis.
View Article and Find Full Text PDFRationale: Treatment efficacy for diabetes mellitus is largely determined by assessment of HbA1c (glycated hemoglobin A1c) levels, which poorly reflects direct glucose variation. People with prediabetes and diabetes mellitus spend >50% of their time outside the optimal glucose range. These glucose variations, termed transient intermittent hyperglycemia (TIH), appear to be an independent risk factor for cardiovascular disease, but the pathological basis for this association is unclear.
View Article and Find Full Text PDFArticle Synopsis
- The study investigated how the renin-angiotensin system (RAS) affects intestinal inflammation and fibrosis through experiments with human colonic myofibroblasts and analysis of patients with inflammatory bowel disease (IBD).
- Results showed that Angiotensin (Ang) 1-7 decreased cell proliferation and collagen secretion in these myofibroblasts, while Ang II had the opposite effects, emphasizing RAS's role in fibrosis.
- Patients with IBD exhibited higher levels of certain RAS components, and those treated with ACE inhibitors or angiotensin receptor blockers had better outcomes, suggesting that targeting the RAS may help improve IBD management.
Background: The intestinal vitamin D receptor (VDR) remains poorly characterized in patients with inflammatory bowel disease (IBD).
Methods: Colonoscopic biopsies and intestinal resection specimens from the terminal ileum, ascending and sigmoid colon, from patients with and without IBD, were analyzed for VDR mRNA quantification by polymerase chain reaction, and protein localization and semi-quantification by immunohistochemistry. The relationship between VDR and intestinal inflammation, serum 25(OH)D and oral vitamin D intake was elicited.