In vitro modelling of anterior primitive streak patterning with human pluripotent stem cells identifies the path to notochord progenitors.

Notochord progenitors (NotoPs) represent a scarce yet crucial embryonic cell population, playing important roles in embryo patterning and eventually giving rise to the cells that form and maintain intervertebral discs. The mechanisms regulating NotoPs emergence are unclear. This knowledge gap persists due to the inherent complexity of cell fate patterning during gastrulation, particularly within the anterior primitive streak (APS), where NotoPs first arise alongside neuro-mesoderm and endoderm.

Acoustic Droplet Vaporization of Perfluorohexane Emulsions Induced by Heterogeneous Nucleation at an Ultrasonic Frequency of 1.1 MHz.

Droplets made of liquid perfluorocarbon undergo a phase transition and transform into microbubbles when triggered by ultrasound of intensity beyond a critical threshold; this mechanism is called acoustic droplet vaporization (ADV). It has been shown that if the intensity of the signal coming from high ultrasonic harmonics are sufficiently high, superharmonic focusing is the mechanism leading to ADV for large droplets (>3 μm) and high frequencies (>1.5 MHz).

[Multifocal ERG using ERG-jet and Gold Foil electrodes in normal subjects: comparison and reproducibility].

Purpose: To compare multifocal electroretinogram (mfERG) amplitudes with the Gold Foil electrode and ERG-jet electrode. To study mfERG amplitude changes between two successive records (intraindividual reproducibility).

Methods: The right eye of 27 normal subjects was examined.

The effect of NeOpuntia on blood lipid parameters--risk factors for the metabolic syndrome (syndrome X).

Metabolic syndrome (syndrome X) causes millions of cardiovascular complications and premature deaths every year. The aim of this study was to evaluate the effects of NeOpuntia, patented, dehydrated, Opuntia ficus-indica leaves, on blood lipid parameters and metabolic syndrome. Opuntia ficus-indica leaves are traditionally consumed as a vegetable.