Prevention of Cardiovascular Events in Patients With Chronic Kidney Disease.

Objective: To examine the evidence base for lifestyle and pharmacologic interventions to reduce the risk of cardiovascular events in patients with chronic kidney disease, with an emphasis on reporting available data in distinct subtypes.

Data Sources: A PubMed search (origin to February 2023) was conducted and references for selected studies were reviewed to identify additional articles. Search terms included chronic kidney disease, major adverse cardiovascular events, and heart failure hospitalization.

Should Antibiotic Allergy Alerts Be Alarming?

Allergies to various antibiotics are reported by a substantial proportion of patients. As a result, clinical decision support programming generates frequent warnings when prescribing within electronic medical records. For a variety of reasons, the majority of these warnings may be inappropriate.

MALAdaptive: do we avoid metformin unnecessarily?

Convention holds that the use of metformin is contraindicated in many patients secondary to concerns about lactic acidosis. However, current evidence suggests that metformin-associated lactic acidosis is at most idiosyncratic. Awareness of the current evidence should permit broader use of this valuable medication.