Publications by authors named "C Tay"

Background: In endemic COVID-19, immunocompromised children are vulnerable until vaccinated but the optimal primary vaccination regime and need for booster doses remains uncertain.

Methods: We recruited 19 immunocompromised children (post-solid organ transplantation, have autoimmune disease or were on current or recent chemotherapy for acute lymphoblastic leukemia), and followed them from the start of primary vaccination with BNT162b2 mRNA SARS-CoV-2 until 1-year post-vaccination. We investigated the quality of vaccine immunogenicity, and longevity of hybrid immunity, in comparison to healthy children.

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Phaeohyphomycosis has been described to cause a variety of cutaneous manifestations in both immunocompetent and immunocompromised hosts. We report an unexpected case where an immunocompetent elderly female developed a rare angioinvasive fungal cutaneous infection. She had no known history of inoculation, and her lesions resolved without treatment.

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Background: Immunoresistance to botulinum neurotoxin A (BoNT-A) due to neutralizing antibodies (NAbs) can lead to partial or complete secondary nonresponse (SNR), potentially limiting individuals' aesthetic and/or medical therapeutic options in the short and/or long term. Understanding factors directly or indirectly influencing BoNT-A immunoresistance risk is crucial.

Aims: This analysis explored patterns of latent risk factors (biological and behavioral) that may influence the risk of developing BoNT-A immunoresistance among experienced aesthetic BoNT-A recipients.

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Article Synopsis
  • Polycystic ovary syndrome (PCOS) is a prevalent health issue that can lead to various reproductive, metabolic, and psychological problems, highlighting the need for a collective approach to establish research priorities in this field.
  • A comprehensive process involving international surveys, systematic reviews, and peer validation revealed over 150 key research priorities, focusing on diagnosis, care models, patient information, lifestyle management, and fertility treatments for those with PCOS.
  • The resulting clinical research roadmap aims to direct future studies according to the needs and interests of women with PCOS and healthcare providers, addressing this commonly overlooked condition.
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