Publications by authors named "C Tardivel"
Background: The effects of supplementation with L-arginine (L-arg), the precursor of nitric oxide (NO), on vascular and cardiometabolic health have largely been explored. Whether other mechanisms of the action of L-arg exist remains unknown, as arginine metabolism is complicated.
Objective: We aimed to characterize the effect of low dose L-arg supplementation on overall human metabolism both in a fasting state and in response to an allostatic stress.
VitB5 level becomes limiting in sarcomas. It is regulated by the pantetheinase activity of VNN1. VNN1 expression in sarcomas is associated with better prognosis and immune infiltration.
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- - Vitamin D deficiency (VDD) is a rising global concern linked to liver fat accumulation in adults, and this study examines its effects on the liver and lipid metabolism of adult offspring based on maternal VDD and diet types.
- - Researchers used various techniques, including liver histology and lipid analysis, and found that while VDD and a high-fat diet did not significantly affect liver structure in either males or females, male offspring of VDD mothers on a high-fat diet showed increased lipid levels and changes in lipid composition.
- - The study concludes that maternal VDD, particularly when paired with a high-fat diet, may lead to specific liver fat changes in male offspring, suggesting that maternal nutrition can influence liver health in future generations.
The tumor microenvironment is a dynamic network of stromal, cancer, and immune cells that interact and compete for resources. We have previously identified the Vanin1 pathway as a tumor suppressor of sarcoma development via vitamin B5 and coenzyme A regeneration. Using an aggressive sarcoma cell line that lacks Vnn1 expression, we showed that the administration of pantethine, a vitamin B5 precursor, attenuates tumor growth in immunocompetent but not nude mice.
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