Publications by authors named "C Tansakul"
High content of reactive oxygen species (ROS) in the human body leads to oxidative stress and serious health problems, such as cancer and cardiovascular or bone diseases. It is also one of the agents that cause collagen damage. Herein, detection of ROS, scavenging of formed carbon-centered radicals and inhibition of collagen fragmentation were performed in a single operation using newly synthesized profluorescent nitroxide PN1 a switch-on approach.
View Article and Find Full Text PDFAscorbic acid (AA) or vitamin C plays multiple crucial roles, particularly as an antioxidant. This essentially biologically active molecule was selectively detected over other reductants by the synthesized profluorescent nitroxide probe ProN6 a switch-on method. After either a hydrogen atom or single electron transfer from AA to nitroxide, the resulting diamagnetic hydroxylamine was rapidly cyclized to form a fluorescent -acylalkoxyamine.
View Article and Find Full Text PDFObjectives: To evaluate the properties of novel hydrolytic resistant antibacterial monomers and to determine the properties of resin adhesives containing these monomers.
Methods: Methacrylamide-based QAC (Quaternary Ammonium Compound) monomers, 1-(11-Methacryla-midoundecyl)pyridine-1-ium bromide (MAUPB) and 1-(12-Methacryl-amidododecyl)pyridine-1-ium bromide (MADPB), and their methacrylate-derivatives, N-(1-Methacryloylundecanyl)pyridinium bromide (MUPB) and N-(1-Methacryloyldodecanyl)pyridinium bromide (MDPB), were synthesized and characterized. The minimum inhibitory (MIC) and bactericidal (MBC) concentrations were determined against S.
Article Synopsis
- Secretory diarrheas, like cholera, are a leading cause of death in young children and result from excessive chloride secretion in the intestines due to enterotoxins.
- Researchers identified five fungal statin derivatives that effectively inhibit cAMP-dependent chloride secretion in human intestinal cells, with the most potent being α,β-dehydrolovastatin (DHLV).
- DHLV showed no cellular toxicity and reduced cholera toxin-induced fluid secretion in mice, indicating its potential as a treatment for enterotoxin-induced diarrheas.
Article Synopsis
- Experimentation showed that it effectively reduced dyslipidemia, liver enzyme levels, and insulin resistance without causing liver or kidney toxicity, outperforming the standard treatment lovastatin.
- The compound also influenced gene expressions related to lipid metabolism and reduced hepatic gluconeogenesis, suggesting its potential as a treatment for dyslipidemia and related metabolic conditions.