Publications by authors named "C Talbotec"
Unlabelled: Facing with an increasing demand for transition to adult care management, our home parenteral nutrition (HPN) team designed an adolescent therapeutic educational program (ATEP) specifically intended for adolescents on long-term HPN. The aim of this study was to report on the first sessions of this program.
Methods: The ATEP is designed in three sessions of five consecutive days, during school holidays over the year.
Article Synopsis
- Sodium dependent multivitamin transporter (SMVT) deficiency is a rare genetic disorder that causes health issues due to a lack of certain vitamins, affecting around 10 known families.
- This study introduced 4 new patients from Algeria, all sharing a specific genetic mutation related to SMVT, confirming its harmful effects through RNA analysis.
- The patients exhibited similar symptoms, including optic atrophy, severe vomiting, and rapid neurological decline, suggesting a common genetic background due to a "founder effect."
Objectives: To analyze the real-life health care costs of home parenteral nutrition (HPN) in children with short bowel syndrome with intestinal failure (SBS-IF) before and after treatment with teduglutide, and to compare those with costs of children with SBS-IF not treated with teduglutide.
Study Design: All consecutive children with SBS-IF on HPN treated with subcutaneous teduglutide starting from 2018 through 2020 in a tertiary French referral center were retrospectively included. These patients were matched to children with SBS-IF on HPN followed during the same 3-year period who were eligible for the teduglutide but were not treated.
Article Synopsis
- Autoimmune polyendocrine syndrome type-1 (APS-1) is linked to mutations in the AIRE gene, leading to multiple autoimmune issues and neutralizing antibodies that cause conditions like mucosal candidiasis and susceptibility to viral infections.
- Ruxolitinib, a JAK inhibitor, was successfully used off-label to treat three APS-1 patients over 30 months without any adverse effects, showing significant improvement in various autoimmune symptoms.
- These findings indicate that JAK inhibitors could be a promising treatment for APS-1 and that further research is warranted to evaluate their effectiveness across a larger patient population.
Intestinal transplant (ITx) rejection lacks a reliable noninvasive biomarker and rejection surveillance relies on serial endoscopies and mucosal biopsies followed by histologic assessment. Endoscopic biopsies are also essential for identifying other ITx-related complications such as infectious, allergic, and inflammatory graft enteritis as well as post-transplant lymphoproliferative disease or graft versus host disease. In spite of its central role in ITx, published guidelines on endoscopy and biopsy are lacking and significant variability between centers in terms of timing and technical performance exists.
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