Publications by authors named "C Talati"
There is a significant need for additional therapy to improve outcomes for newborns with acute Hypoxic-ischemic (HI) encephalopathy (HIE). New evidence suggests that insulin could be neuroprotective. This study aimed to investigate whether intranasal insulin attenuates HI-induced brain damage and neurobehavioral dysfunction in neonatal rats.
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- Acute myeloid leukemia (AML) outcomes are influenced by genetic factors, with NPM1 mutations found in about 30% of cases and linked to a better prognosis.
- This study involving 233 AML patients showed that those with secondary mutations (sMut) had significantly lower overall survival rates compared to those without sMut, even when considering favorable-risk AML.
- Among patients who achieved measurable residual disease negativity, those with sMut still had poorer survival compared to MRD negative patients, highlighting the adverse impact of sMut on prognosis in AML.
Hispanic patients have been reported to have an increased incidence of AML and possibly inferior outcomes compared to non-Hispanics. We conducted a retrospective study of 225 AML patients (58 Hispanic and 167 non-Hispanic) at two academic medical centers in Florida. Disease characteristics, cytogenetics, mutation profiles, and clinical outcomes were assessed.
View Article and Find Full Text PDFBackground: Genomic landscape of extramedullary acute myeloid leukemia (EM-AML), including myeloid sarcoma (MS) and leukemia cutis (LC), is not well characterized. The potential utility of next-generation sequencing (NGS) using EM tissue is not established.
Methods: In this multicenter retrospective study, clinical and NGS data were collected on patients with EM-AML.