Publications by authors named "C Taibi"
The hepatitis delta virus (HDV) exhibits high genetic and evolutionary variability and is classified into eight genotypes (HDV-1 to -8). HDV-1 is the most widespread genotype worldwide and includes several subtypes. It predominates mainly in Europe, the Middle East, North America, and Northern Africa, and is associated with both severe and mild forms of liver disease.
View Article and Find Full Text PDFObjectives: We describe the preliminary results of bulevirtide compassionate use in patients with hepatitis B and delta virus (HBV/HDV)-related cirrhosis and clinically significant portal hypertension, including those living with HIV.
Methods: We conducted a prospective observational study of consecutive patients. Clinical evaluation, liver function tests, bile acid levels, HDV-RNA, HBV-DNA, hepatitis B surface antigen, and liver and spleen stiffness were assessed at baseline and after treatment months 1, 2, 3, 4, 6, 9, and 12.
Coronavirus-disease-2019 (COVID-19) mRNA vaccination effectively reduces mortality and morbidity in cirrhotic patients, but the immunogenicity and safety of vaccination have been partially characterized. The study aimed to evaluate humoral response, predictive factors, and safety of mRNA-COVID-19 vaccination in cirrhotic patients compared to healthy subjects. A prospective, single-center, observational study enrolled consecutive cirrhotic patients who underwent mRNA-COVID-19 vaccination from April to May 2021.
View Article and Find Full Text PDFArticle Synopsis
- Asymptomatic individuals make up a significant portion (25-45%) of SARS-CoV-2 infections, particularly among those on mild immunosuppressive therapy, leading to potential extended virus spread.
- A study involving 278 liver transplant recipients in Central Italy found that serology testing every four months effectively increased infection detection rates, revealing that 31 individuals had either past or active SARS-CoV-2 infections.
- The research indicated that factors like gender and kidney function affected the likelihood of being asymptomatic, and the overall anti-SARS-CoV-2 seroprevalence among liver transplant recipients was similar to the general population in the region (11.2%).