Publications by authors named "C Taffon"
Epithelial-to-mesenchymal transition (EMT) is a biological process by which epithelial cells increase their motility and acquire invasive capacity. It represents a crucial driver of cancer metastasis and peritoneal dissemination. EMT plasticity, with cells exhibiting hybrid epithelial/mesenchymal states, and its reverse process, mesenchymal-to-epithelial transition (MET), allows them to adapt to different microenvironments and evade therapeutic intervention.
View Article and Find Full Text PDFParathyroid carcinoma (PC) is a rare endocrine malignancy that poses significant diagnostic challenges due to its resemblance to benign conditions. This case series describes the clinical presentation, diagnosis, management, and short-term outcomes of four male patients (aged 54, 65, 73, and 74 years) with primary hyperparathyroidism and hypercalcemia. The preoperative diagnosis of PC remains challenging; suspicion should arise in cases of severe hypercalcemia, elevated parathyroid hormone levels, and the presence of a mass on imaging or during surgery.
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- - Ex vivo fluorescence laser scanning microscopy (FCM) enables real-time imaging of fresh tissue samples without traditional slide preparation, and this study specifically investigates its application in evaluating biopsy samples from endoscopic procedures for lung lesions and lymph nodes.
- - The study involved 32 patients, showing that the FCM Vivascope 2500 could accurately assess sample adequacy and malignancy, with a perfect agreement noted between its evaluations and final histological results.
- - The findings suggest that FCM could significantly improve the speed of diagnostic information during endoscopic biopsies, potentially enhancing patient management by reducing the time needed to diagnose lung cancer.
Article Synopsis
- Antineutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (AAV) primarily targets small- and medium-sized arteries, leading to conditions like rapidly progressive glomerulonephritis, particularly affecting the kidneys.
- Infections are known triggers for this autoimmune disorder, and recent studies suggest a link between SARS-CoV-2 infection and acute kidney injury (AKI).
- The text presents a specific case of a 61-year-old man who developed new-onset diffuse proliferative ANCA-associated glomerulonephritis following COVID-19.
Article Synopsis
- * In a study of 28 patients, RS was used to analyze thyroid cytological samples from fine needle aspirations (FNA) to evaluate cell oxidative stress, a major cancer risk factor.
- * The findings categorized patients based on changes in Raman spectra related to oxidative stress and carotenoid presence, suggesting a link between oxidative stress and thyroid diseases that could inform future research on biomarkers.