Inhibition of Soluble Epoxide Hydrolase by Cembranoid Diterpenes from Soft Coral : Enzyme Kinetics, Molecular Docking, and Molecular Dynamics.

Soluble epoxide hydrolase (sEH) is essential for converting epoxy fatty acids, such as epoxyeicosatrienoic acids (EETs), into their dihydroxy forms. EETs play a crucial role in regulating blood pressure, mediating anti-inflammatory responses, and modulating pain, making sEH a key target for therapeutic interventions. Current research is increasingly focused on identifying sEH inhibitors from natural sources, particularly marine environments, which are rich in bioactive compounds due to their unique metabolic adaptations.

Acylated flavonoid glycosides from Barringtonia pendula and their inhibition on lipopolysaccharide-induced nitric oxide production in RAW264.7 cells.

Six new acylated flavonoid glycosides namely barringosides J - O (1-6) along with tephrokaempferoside and barringoside D were isolated from the branches and leaves of Barringtonia pendula. The structural elucidation was confirmed by extensive analysis of their spectroscopic data including HRQTOFMS, 1D and 2D NMR experiments. Moderate inhibitory effects on LPS-induced NO production in RAW264.

Diterpenoid and phenolic constituents from corn silk () with PTP1B inhibitory activity.

Chemical investigation of corn silk resulted in the isolation of nine secondary metabolites, including a new -kaurane diterpenoid, zeamaysditerpene A () and eight known compounds, stigmaydene A (), stigmaydene J (), stigmaydene L (), stigmane D (), demethyltorosaflavone D (), chrysoeriol 6---boivinopyranosyl-7---D-glucopyranoside (), deoxypodophyllotoxin (), and -peltatin glucoside (). Their structures were elucidated using a combination of spectroscopic methods, including 1D and 2D NMR and HRESIQTOF mass spectra. The absolute configuration of was deduced by applying electronic circular dichroism (ECD) calculation method.

Isoryanodane diterpene derivatives from .

From the MeOH residue of branches and leaves, one new isoryanodane diterpene, barringisol (), and two new isoryanodane diterpene glucosides, barringisosides A and B ( and ), were obtained using various chromatographic isolations. The structural characterization was confirmed by spectroscopic methods including 1D, 2D NMR and HR-ESI-QTOF-MS. This is the first isolation of isoryanodane diterpene derivatives from species.