Publications by authors named "C TURAN"
Thoracoabdominal normothermic regional perfusion (TA-NRP), a new method of controlled donation after circulatory death, seems to provide more and better organs for patients on organ transplant waiting lists compared to standard controlled donation after circulatory death. Despite its benefits, the ethical permissibility of TA-NRP is currently a highly debated issue. The recent statement published by the American College of Physicians (ACP) highlights the reasons for these debates.
View Article and Find Full Text PDFBackground: Idiopathic pulmonary fibrosis (IPF) is a progressive, deadly lung disease with several factors, including respiratory tract infections (RTI), for disease worsening. There's no comprehensive data on RTI incidence in IPF patients across different therapies, including antifibrotic (nintedanib or pirfenidone), investigative or placebo treatments.
Methods: A systematic search of databases Medline, EMBASE, Cochrane Central, Web of Science and Scopus was conducted on September 30th 2024 (PROSPERO registration number: CRD42023484213).
Article Synopsis
- - The study investigates the effectiveness of different balloon treatments after rotational atherectomy (RA) for calcified coronary lesions, focusing on whether modified balloons (MB) improve outcomes compared to plain balloon angioplasty (BA).
- - A meta-analysis of nine studies involving 1,024 patients found no significant differences in major adverse cardiovascular events, all-cause mortality, or target lesion revascularization between the RA + BA and RA + MB groups overall.
- - However, the analysis revealed that for patients with severely calcified lesions, the RA + MB group experienced significantly fewer major adverse cardiovascular events without increasing procedural complications.
Progressive atelectasis regularly occurs during general anaesthesia; hence, positive end-expiratory pressure (PEEP) is often applied. Individualised PEEP titration may reduce the incidence of postoperative pulmonary complications (PPCs) and improve oxygenation as compared to fixed PEEP settings; however, evidence is lacking. This systematic review and meta-analysis was registered on PROSPERO (CRD42021282228).
View Article and Find Full Text PDFArticle Synopsis
- Genome-Wide Non-Invasive Prenatal Testing (GW-NIPT) can detect not just common chromosomal abnormalities but also rare autosomal trisomies and structural chromosomal issues, though data on their predictive value is limited.
- The study analyzed 17 publications covering 740,076 cases to assess the accuracy of GW-NIPT for rare abnormalities, utilizing both confirmed and extended methodologies to define true positive cases.
- Findings highlighted that T16, T22, and T15 had the highest rates of true positives, providing essential insights for genetic counseling and improving decision-making for patients and healthcare providers.