Chernobyl nuclear catastrophe: lessons for sustainability and UNSDGs in health, energy, and environmental recovery.

This study provides a comprehensive review of the research surrounding the Chernobyl nuclear incident, focusing on its far-reaching impacts on human health, and environmental contamination. Based on the Scopus database, 258 relevant papers were identified using Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. These papers were metal-analyzed and quantitatively analyzed using a similarity map generated through VOSViewer in order to visualize key themes and their interconnections.

Feedback Attention to Enhance Unsupervised Deep Learning Image Registration in 3D Echocardiography.

Cardiac motion estimation is important for assessing the contractile health of the heart, and performing this in 3D can provide advantages due to the complex 3D geometry and motions of the heart. Deep learning image registration (DLIR) is a robust way to achieve cardiac motion estimation in echocardiography, providing speed and precision benefits, but DLIR in 3D echo remains challenging. Successful unsupervised 2D DLIR strategies are often not effective in 3D, and there have been few 3D echo DLIR implementations.

3D velocity and pressure field reconstruction in the cardiac left ventricle via physics informed neural network from echocardiography guided by 3D color Doppler.

Fluid dynamics of the heart chamber can provide critical biological cues for understanding cardiac health and disease and have the potential for supporting diagnosis and prognosis. However, directly acquiring fluid dynamics information from clinical imaging remains challenging, as they are often noisy and have limited resolution, preventing accurate detailed fluid dynamics analysis. Image-based flow simulations offer high detail but are typically difficult to align with clinical velocity measurements, and as a result, may not accurately depict true fluid dynamics.

Adenine phosphoribosyltransferase (APRT) deficiency: an increasingly recognized disease.

Adenine phosphoribosyltransferase (APRT) deficiency is a rare autosomal recessive disorder which causes high urinary 2,8-dihydroxyadenine (2,8-DHA) excretion, resulting in urolithiasis and crystal nephropathy. It is caused by mutations in the APRT gene. Even though it is an inherited kidney stone disease, the varied clinical presentations, even within a family with the same underlying genetic variants, can lead to delayed diagnosis with some only being recognized in adulthood and even, following a kidney transplant.

Multi-omics analysis in primary T cells elucidates mechanisms behind disease-associated genetic loci.

Background: Genome-wide association studies (GWAS) have uncovered the genetic basis behind many diseases and conditions. However, most of these genetic loci affect regulatory regions, making the interpretation challenging. Chromatin conformation has a fundamental role in gene regulation and is frequently used to associate potential target genes to regulatory regions.