Implications of the choroid plexus in Niemann-Pick disease Type C neuropathogenesis.

Background: Niemann-Pick Disease Type C (NPC) is an ultra-rare disorder characterized by progressive psychiatric and neurologic manifestations, with late infantile, juvenile, and adolescent/adult presentations. We examined morphological properties of the choroid plexus, a protective blood-cerebrospinal fluid barrier, in NPC, and their relationship with neurodegeneration, clinical status, and circulatory markers. This study also determined whether choroid plexus morphology differentiates between NPC and more prevalent illnesses, schizophrenia (SZ) and bipolar disorder (BD), which have overlapping psychiatric symptoms with adolescent and adult-onset NPC and are associated with misdiagnosis.

Installation of Copper(I) and Silver(I) Sites into TREN-Based Porous Organic Cages via Postsynthetic Metalation.

Porous organic cages (POCs) and metal-organic polyhedra (MOPs) function as zero-dimensional porous materials, able to mimic many functions of insoluble framework materials while offering processability advantages. A popular approach to access tailored metal-based motifs in extended network materials is postsynthetic metalation, which allows metal installation to be decoupled from framework assembly. Surprisingly, this approach has only sparingly been reported for molecular porous materials.

Edited eukaryotic translation initiation factors confer resistance against maize lethal necrosis.

Maize lethal necrosis (MLN), which is caused by maize chlorotic mottle virus along with a potyvirus, has threatened the food security of smallholders in sub-Saharan Africa. Mutations in eukaryotic translation initiation factors (eIFs), which also facilitate virus genome translation, are known to confer variable resistance against viruses. Following phylogenetic analysis, we selected two eIF4E proteins from maize as the most likely candidates to facilitate MLN infection.