BMP and STRA8 act collaboratively to ensure correct mitotic-to-meiotic transition in the fetal mouse ovary.

A successful mitosis-to-meiosis transition in germ cells is essential for fertility in sexually reproducing organisms. In mice and humans, it is established that expression of STRA8 is critical for meiotic onset in both sexes. Here we show that BMP signalling is also essential, not for STRA8 induction but for correct meiotic progression in female mouse fetal germ cells.

Rare and common genetic variants underlying the risk of Hirschsprung's disease.

Hirschsprung's disease (HSCR) is a congenital enteric neuropathic disorder characterized by high heritability (>80%) and polygenic inheritance (>20 genes). The previous genome-wide association studies (GWAS) identified several common variants associated with HSCR and demonstrated increased predictive performance for HSCR risk in Europeans using a genetic risk score, there remains a notable gap in knowledge regarding Chinese populations. We conducted whole exome sequencing in a HSCR case cohort in Chinese.

Deteriorating Hypotension and Trepopnea During Left Lateral Decubitus Position Before Spinal Anesthesia.

We presented two cases in which patients with chronic heart failure experienced significant hypotension and respiratory distress during the left lateral decubitus position before spinal anesthesia for orthopedic surgery.

Unraveling the in vivo pharmacokinetic behavior of mPEG-NH polymer in rats by UHPLC-MS/MS assay.

As an important chemical reagent, methoxy polyethylene glycol amine (mPEG-NH) is widely used in biomedical field. Unraveling the pharmacokinetic behavior of mPEG-NH polymers is essential for revealing the toxicity and efficiency of mPEG-NH related drug delivery systems. In this study, a simple analytical assay based on mass spectrometry (MS) was first established and validated for quantification of mPEG-NH in biological matrix.

Advances in lysosomal escape mechanisms for gynecological cancer nano-therapeutics.

Gynecological cancers present significant treatment challenges due to drug resistance and adverse side effects. This review explores advancements in lysosomal escape mechanisms, essential for enhancing nano-therapeutic efficacy. Strategies such as pH-sensitive linkers and membrane fusion are examined, showcasing their potential to improve therapeutic outcomes in ovarian, cervical, and uterine cancers.