Publications by authors named "C T Crowe"
Purpose: Brachial plexus traction injuries have conventionally been categorized as involving the C5-C6, C5-C7, C5-T1, and C8-T1 roots. In this article, we report a distinct clinical presentation of brachial plexus injury characterized by intact finger flexion with signs of complete brachial plexus injury.
Methods: From 2010 to 2022, 989 patients who sustained brachial plexus injuries were examined and underwent surgery.
Article Synopsis
- Medication adjustments for Parkinson's disease are based on patient feedback and clinicians' assessments of motor symptoms like bradykinesia and tremor.
- This study evaluates how consistently different clinicians assess upper limb motor function in Parkinson's patients during video recordings of standardized hand movements.
- Results show that initial agreement among clinicians was poor, especially for certain movements, but training improved their consistency in ratings significantly.
Article Synopsis
- Small-molecule degraders can effectively target and degrade disease-driving proteins, offering a new approach for treating previously untreatable conditions.
- Researchers used cryo-EM to observe how the degrader MZ1 helps position the Brd4 protein for ubiquitination by the UBE2R1 enzyme, leading to its degradation.
- The study identifies specific lysines on Brd4 that are prone to ubiquitination and suggests a flexible model for how degrader-induced targets could be modified for better drug development.
Motor symptoms such as tremor and bradykinesia can develop concurrently in Parkinson's disease; thus, the ideal home monitoring system should be capable of tracking symptoms continuously despite background noise from daily activities. The goal of this study is to demonstrate the feasibility of detecting symptom episodes in a free-living scenario, providing a higher level of interpretability to aid AI-powered decision-making. Machine learning models trained on wearable sensor data from scripted activities performed by participants in the lab and clinician ratings of the video recordings of these tasks identified tremor, bradykinesia, and dyskinesia in the supervised lab environment with a balanced accuracy of 83%, 75%, and 81%, respectively, when compared to the clinician ratings.
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- Galcanezumab is a medicine used to help prevent migraines in adults, especially women who might get pregnant, but we don't know much about its safety during pregnancy yet.
- There's a study tracking pregnancies where women took galcanezumab, using health insurance data from September 2018 to June 2026, and they need 430 such cases to learn more about any potential risks.
- So far, they've found 207 pregnancies linked to the medicine but need many more to complete the study, which is an obstacle in getting safer pregnancy information out to doctors and patients.