Publications by authors named "C T Cho"
Membrane-forming phospholipids are generated in cells by enzymatic diacylation of non-amphiphilic polar head groups. Analogous non-enzymatic processes may have been relevant at the origin of life and could have practical utility in membrane synthesis. However, aqueous head group diacylation is challenging in the absence of enzymes.
View Article and Find Full Text PDFInductively coupled plasma-reactive etching (ICP-RIE) of InGaZnO (IGZO) thin films was studied with variations in gas mixtures of hydrochloride (HCl) and argon (Ar). The dry etching characteristics of the IGZO films were investigated according to radiofrequency bias power, gas mixing ratio, and chamber pressure. The IGZO film showed an excellent etch rate of 83.
View Article and Find Full Text PDFCoordinated expression of replication-dependent (RD) histones genes occurs within the Histone Locus Body (HLB) during S phase, but the molecular steps in transcription that are cell cycle regulated are unknown. We report that RNA Pol II promotes HLB formation and is enriched in the HLB outside of S phase, including G1-arrested cells that do not transcribe RD histone genes. In contrast, the transcription elongation factor Spt6 is enriched in HLBs only during S phase.
View Article and Find Full Text PDFArticle Synopsis
- Gliclazide is a medication for type 2 diabetes, primarily metabolized by genetic variations in the CYP2C9 and CYP2C19 enzymes.
- A physiologically based pharmacokinetic (PBPK) model was developed to analyze how these genetic differences affect gliclazide's effects in patients.
- The model accurately predicted drug concentration levels in the bloodstream, meeting standard evaluation criteria and potentially paving the way for personalized treatment plans based on genetic profiles.
Background: Human placental hydrolysate (hPH) contains anti-inflammatory substances. This study aimed to analyze whether injecting hPH into the subacromial space could reduce pain in patients with shoulder impingement syndrome.
Methods: This single-blind, randomized controlled study enrolled 50 patients with shoulder impingement syndrome who were randomly assigned to either the hPH or placebo groups.