Publications by authors named "C T Bowles"

We sought to remedy the limited guidance that is available to support the resuscitation of patients with the Impella Cardiac Power (CP) and 5.0 devices during episodes of cardiac arrest or life-threatening events that can result in haemodynamic decompensation. In a specialist tertiary referral centre we developed, by iteration, a novel resuscitation algorithm for Impella emergencies, which we validated through simulation and assessment by our multi- disciplinary team.

View Article and Find Full Text PDF

Background: We evaluated the potential benefits of renin-angiotensin-aldosterone system inhibitors (RAASi) in patients with left ventricular assist device support.

Methods And Results: A total of 165 consecutive patients undergoing left ventricular assist device implant and alive at 6-month on support were studied. RAASi status after 6-month visit along with clinical reasons for nonprescription/uptitration were retrospectively assessed.

View Article and Find Full Text PDF
Article Synopsis
  • An implantable left ventricular assist device (LVAD) is used in the UK mainly as a temporary solution for patients awaiting heart transplants or recovery.
  • LVADs create a unique hemodynamic state, making standard measurements like blood pressure and pulse difficult to obtain, leading to challenges in patient assessment.
  • To address these challenges, UK experts developed specific guidelines for managing emergencies in LVAD patients, aimed at healthcare providers in advanced heart failure centers, ensuring appropriate care during critical situations.
View Article and Find Full Text PDF
Article Synopsis
  • The study examines the integration of genomic data across NHS laboratories in England and Wales, highlighting variations in data structure, quality, and ease of local assembly for cancer susceptibility gene testing.
  • A survey of 51 clinical scientists revealed significant differences in how variant data is transferred, formatted, and classified within Laboratory Information Management Systems (LIMS) across the participating labs.
  • The findings indicate that current workflows are often inefficient and prone to errors due to their manual nature, suggesting that implementing recommended improvements could streamline data submission processes for better national and international collaboration.
View Article and Find Full Text PDF