Publications by authors named "C Sumi"
Article Synopsis
- Patients undergoing elective pelvic exenteration surgery are at risk of getting inadequate concentrations of the antibiotics piperacillin and tazobactam during surgery.
- This study aimed to analyze how these antibiotics are processed in the body (pharmacokinetics) and to find better dosing recommendations to ensure effective levels during surgery.
- Results showed that a lower continuous infusion dosage of piperacillin/tazobactam is effective in maintaining proper antibiotic levels, but patients with higher weights and kidney function might need higher doses to avoid suboptimal exposure.
Background: Accumulating evidence has suggested that neuropeptides such as orexin, ghrelin, or oxytocin act centrally in the brain to regulate intestinal barrier function through the vagus nerve. It has been reported that the vagal cholinergic anti-inflammatory pathway was blocked by splenectomy. In the present study, we therefore examined the effect of splenectomy on neuropeptides-induced improvement of increased intestinal permeability.
View Article and Find Full Text PDFDrug treatments for coronavirus disease 2019 (COVID-19) dramatically improve patient outcomes, and although extracorporeal membrane oxygenation (ECMO) has significant use in these patients, it is unknown whether ECMO affects drug dosing. We used an ex vivo adult ECMO model to measure ECMO circuit effects on concentrations of specific COVID-19 drug treatments. Three identical ECMO circuits used in adult patients were set up.
View Article and Find Full Text PDFOsteoblast-derived semaphorin3A (Sema3A) has been reported to be involved in bone protection, and Sema3A knockout mice have been reported to exhibit chondrodysplasia. From these reports, Sema3A is considered to be involved in chondrogenic differentiation and skeletal formation, but there are many unclear points about its function and mechanism in chondrogenic differentiation. This study investigated the pharmacological effects of Sema3A in chondrogenic differentiation.
View Article and Find Full Text PDFBackground And Aims: Multiple myeloma (MM), a neoplasm of plasma cells (PCs), is a highly heterogeneous disease with multifocal dissemination throughout the body. Minimal residual disease (MRD) detected using PCs in bone marrow (BM) is important for MM management; however, frequent invasive examinations impose a significant burden on patients.
Methods: Analysis using plasma cell-free DNA (cfDNA) might represent an alternative tool for disease monitoring.