Publications by authors named "C Suffritti"
Background: Although more than four years have passed since the pandemic began, SARS-CoV-2 continues to be of concern. Therefore, research into the underlying mechanisms that contribute to the development of the disease, especially in more severe forms, remains a priority. Sustained activation of the complement (CS), contact (CAS), and fibrinolytic and kinin-kallikrein systems (KKS) has been shown to play a central role in the pathogenesis of the disease.
View Article and Find Full Text PDFExploring the management of recurrent angioedema caused by different mechanisms.
Curr Opin Allergy Clin Immunol
February 2025
Purpose Of Review: We aim to explore the most recent insights into the pathogenesis of recurrent angioedema caused by different mechanisms and then focus on the management and treatment approaches available.
Recent Findings: The recently developed DANCE consensus classification identifies five types of angioedema: mast cell-mediated (AE-MC), bradykinin-mediated, because of intrinsic vascular endothelium dysfunction (AE-VE), drug-induced (AE-DI), and due to unknown mechanisms (AE-UNK). These subtypes require different management with treatment choices targeting the main pathogenetic pathways involved in each form.
Article Synopsis
- Doctors are now focusing on helping people with hemophilia keep their joints healthy and improve their quality of life instead of just stopping life-threatening bleeding.
- Ultrasound is a helpful tool for quickly finding joint problems and can work with technology like artificial intelligence and telemedicine for better ongoing care.
- Working with different types of doctors and therapists early on can help patients live a healthier and happier life.
Article Synopsis
- Hereditary angioedema (HAE) is a rare genetic disorder causing episodes of swelling, particularly due to an increase in a substance called bradykinin, especially in patients with mutations in the F12 gene that affect C1 inhibitor activity.
- A study comparing 40 patients with FXII-HAE to 40 healthy individuals found increased plasma levels of specific lipid mediators and enzymes, indicating an altered biochemical response in those with the condition.
- The findings suggest that the overproduction of bradykinin impacts certain pathways in FXII-HAE, opening up potential avenues for further research on the role of these lipid mediators in the disease.
Contact System Activation and Bradykinin Generation in Patients With Idiopathic Angioedema.
J Investig Allergol Clin Immunol
October 2024