Publications by authors named "C Suebthawinkul"
Background: Frozen embryo transfer (FET) has been increasingly used due to advancements in cryopreservation techniques and the safety advantages. This study aims to determine various factors influencing the successful FET.
Materials And Methods: Retrospective cohort analysis included 1112 women who underwent programmed FET between January 2012 and October 2022, at King Chulalongkorn Memorial Hospital, Thailand.
Article Synopsis
- The study explored how fibrin-based hydrogel encapsulation impacted ovarian tissue quality and cell survival after freezing
- The research involved four groups of ovarian cortex from patients aged 44-47, comparing fresh tissue, uncapsulated tissue, and two encapsulated conditions (with and without VEGF)
- Key findings showed that encapsulation helped maintain signaling pathways important for cell survival, although some unfavorable effects on certain expression levels were noted, suggesting a need for further research to enhance this technique for fertility preservation.
Embryo Selection for IVF using Machine Learning Techniques Based on Light Microscopic Images of Embryo and Additional Factors.
Annu Int Conf IEEE Eng Med Biol Soc
July 2023
The current process of embryo selection in In Vitro Fertilization (IVF) process is based on morphological criteria, e.g., Istanbul scoring system and manually evaluated by embryologists; consequently, the assessment can be subjective.
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- Follicular fluid (FF) is crucial for oocyte development but its effects on oocytes are not fully understood, especially due to the difficulty in collecting enough human oocytes for research.
- Researchers used mouse oocytes in human FF to explore how varying FF concentrations affect gamete quality, discovering that higher concentrations (>10%) actually hindered meiotic progress and caused defects.
- The study also revealed that FF's effects on oocyte quality are influenced by the age of the donor, showing that FF from younger donors supports meiotic progression better than that from older donors, with potential implications for fertilization and embryo development.
Reproductive aging is associated with ovulatory defects. Age-related ovarian fibrosis partially contributes to this phenotype as short-term treatment with anti-fibrotic compounds improves ovulation in reproductively old mice. However, age-dependent changes that are intrinsic to the follicle may also be relevant.
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