Publications by authors named "C Sturiale"

Background: Fusiform aneurysms are a distinct subgroup of intracranial aneurysms with unique characteristics and pose a treatment challenge compared to common saccular aneurysms. Traditionally, surgery was the main treatment; however, endovascular techniques are gaining favor.

Methods: We searched major databases for studies on treatment, clinical outcomes, and radiological outcomes of intracranial fusiform aneurysms published before May 31st, 2023 in order to compare surgical Vs endovascular treatment strategies.

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Spinal dural arteriovenous fistulas (dAVFs) are a rare type of spinal lesion that can cause severe clinical consequences. Early and accurate diagnosis and treatment are crucial to avoid severe complications such as radicular pain, weakness, sensory deficits, and loss of bowel and bladder control. Spinal dAVFs are commonly found in the lower thoracic or upper lumbar vertebrae.

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Article Synopsis
  • Glioblastoma (GBM) is a highly aggressive brain tumor with a low five-year survival rate of only 6.8%, and current treatment methods have not changed in over a decade despite advances in understanding its biology.
  • The hTERT promoter mutations, found in up to 80% of GBM cases, present a potential target for therapy through telomerase inhibition, which is essential for cancer cell proliferation.
  • This systematic review analyzed 777 articles to assess telomerase-targeted therapies, revealing that while some compounds show promise in preclinical stages, they often fail in clinical trials due to complex biological challenges and poor pharmacokinetics.
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Background: Spontaneous non-traumatic subarachnoid hemorrhage (sSAH) is a severe brain vascular accident. Glial fibrillary acidic protein (GFAP) and ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) can be theoretically assayed to predict a patient's progression, picturing different aspects of clinical failure after sSAH. The study aims to: a) explore the correlation between sSAH blood volume and biomarkers variation; b) evaluate if these can be predictive of the neurogenic response after sSAH and be prognostic of patient outcome; c) establish eventual threshold levels of biomarkers to define patients' clinical outcome.

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