Publications by authors named "C Stubbs"
Article Synopsis
- Chronic or gestational hypertension affects about 7% of pregnancies, and the WILL Trial aimed to find the best timing for delivery to improve outcomes for mothers and babies.
- The trial involved women with hypertension at 36 to 37 weeks gestation who were randomly assigned to either an early delivery intervention at 38 weeks or usual care at term, analyzing maternal and neonatal outcomes.
- Despite aiming for 540 participants, the trial ended early with only 403 participants due to slow recruitment, showing no significant difference in poor maternal outcomes between the two groups, while deliveries in the intervention group occurred about 0.9 weeks earlier.
Article Synopsis
- Endometriosis affects 1 in 10 women, often leading to surgery for persistent pain, but symptoms frequently recur post-operation, creating uncertainty about the most effective hormonal treatments.
- A study was conducted across 34 UK hospitals to compare the effectiveness of long-acting progestogen therapy with the combined oral contraceptive pill in preventing pain recurrence and improving quality of life after surgery.
- Results showed both treatment options reduced pain compared to pre-surgery levels, but no significant difference in effectiveness was found between the two, although fewer follow-up procedures were needed for those on long-acting progestogen.
Article Synopsis
- Second trimester miscarriage and preterm birth are significant issues globally, leading to the use of surgical cervical cerclage to help prevent these outcomes, with a focus on comparing the effectiveness of monofilament versus braided sutures.
- The study aims to determine if monofilament sutures reduce pregnancy loss better than braided ones in women needing cervical cerclage, as bacteria colonization on braided sutures may contribute to complications.
- Conducted across 75 UK maternity sites, this open randomized controlled trial includes women with specific risk factors for preterm birth and evaluates outcomes like miscarriage rates and perinatal mortality through a 1:1 randomization process.
PRMT5, a type 2 arginine methyltransferase, has a critical role in regulating cell growth and survival in cancer. With the aim of developing MTA-cooperative PRMT5 inhibitors suitable for MTAP-deficient cancers, herein we report our efforts to develop novel "MTA-cooperative" compounds identified through a high-throughput biochemical screening approach. Optimization of hits was achieved through structure-based design with a focus on improvement of oral drug-like properties.
View Article and Find Full Text PDFMUS81 is a structure-selective endonuclease that cleaves various branched DNA structures arising from natural physiological processes such as homologous recombination and mitosis. Due to this, MUS81 is able to relieve replication stress, and its function has been reported to be critical to the survival of many cancers, particularly those with dysfunctional DNA-repair machinery. There is therefore interest in MUS81 as a cancer drug target, yet there are currently few small molecule inhibitors of this enzyme reported, and no liganded crystal structures are available to guide hit optimization.
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